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Survival with Cardiac-Resynchronization Therapy in Mild Heart Failure
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Survival with Cardiac-Resynchronization Therapy in Mild Heart Failure
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Journal Article
Survival with Cardiac-Resynchronization Therapy in Mild Heart Failure
2014
Overview
In patients with reduced ejection fraction, mild heart failure, and prolonged QRS duration, CRT with a defibrillator improved survival, as compared with defibrillator therapy alone. The survival benefit was limited to patients with left bundle-branch block.
The Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) showed the safety and effectiveness of cardiac-resynchronization therapy (CRT) with a defibrillator (CRT-D) in patients with asymptomatic or mildly symptomatic heart failure, a reduced ejection fraction, and a prolonged QRS duration.
1
The study showed that treatment with CRT-D was associated with a 34% relative reduction in the risk of nonfatal heart-failure events or death from any cause, as compared with implantable cardioverter–defibrillator (ICD) therapy alone over a median follow-up period of 2.4 years. The benefit of CRT-D in the trial was primarily driven by a significant relative reduction of . . .
Publisher
Massachusetts Medical Society
Subject
/ Biological and medical sciences
/ Bundle-Branch Block - complications
/ Bundle-Branch Block - therapy
/ Cardiac Resynchronization Therapy
/ Female
/ Heart
/ Heart Failure - complications
/ Heart Failure - prevention & control
/ Heart failure, cardiogenic pulmonary edema, cardiac enlargement
/ Humans
/ Male
/ Patients
/ Survival
