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Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)

by Alessandrini, Marco , Mazzatenta, Andrea , Micarelli, Alessandro , Migliore, Alberto , Caccamo, Daniela , Piroli, Alba , Bianca, Margherita , Tapparo, Ottaviano , Guzzi, Gianpaolo , Damiani, Giovanni , Pigatto, Paolo , Cormano, Andrea

in Agreements / Allergies / Consensus / Dermatology / Epidemiology / Humans / Hypersensitivity / Immunoglobulins / Italy - epidemiology / Multiple Chemical Sensitivity - diagnosis / Multiple Chemical Sensitivity - epidemiology / Multiple Chemical Sensitivity - therapy / Nervous system / Otolaryngology / Pathogenesis / Patients / Questionnaires / Severe acute respiratory syndrome coronavirus 2 / Society / Solvents / Systematic review

2021

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Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)

2021

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Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)

2021

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Journal Article

Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)

Alessandrini, Marco,

Mazzatenta, Andrea,

Micarelli, Alessandro,

Migliore, Alberto,

Caccamo, Daniela,

Piroli, Alba,

Bianca, Margherita,

Tapparo, Ottaviano,

Guzzi, Gianpaolo,

Damiani, Giovanni,

Pigatto, Paolo,

Cormano, Andrea

2021

Overview

Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome characterized by cutaneous, allergic, gastrointestinal, rheumatological, endocrinological, cardiological and neurological signs and symptoms. We performed a systematic review of the literature to summarize the current clinical and therapeutic evidence and then oriented an eDelphi consensus. Four main research domains were identified (diagnosis, treatment, hospitalization and emergency) and discussed by 10 experts and an MCS patient. Thus, the first Italian MCS consensus had the double aim: (a) to improve MCS knowledge among healthcare workers and patients by standardizing the clinical and therapeutic management to MCS patients; and (b) to improve and shed light on MCS misconceptions not supported by evidence-based medicine (EBM).

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Publisher

MDPI AG,MDPI

Subject

/ Humans