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Randomized Trial of Closed-Loop Control in Very Young Children with Type 1 Diabetes

by Thankamony, Ajay , Hovorka, Roman , Boughton, Charlotte K , Lawton, Julia , Kapellen, Thomas M , Campbell, Fiona M , Yong, James , Hood, Korey K , Roze, Stephane , Fröhlich-Reiterer, Elke , Sibayan, Judy , Schierloh, Ulrike , de Beaufort, Carine , Nagl, Katrin , Hartnell, Sara , Hofer, Sabine E , Tauschmann, Martin , Kollman, Craig , Wilinska, Malgorzata E , Ware, Julia , Mader, Julia K , Bocchino, Laura E , Allen, Janet M , Rami-Merhar, Birgit

in Adverse events / Age groups / Algorithms / Blood Glucose - analysis / Caregivers / Child / Child, Preschool / Childhood Diseases / Children / Closed loop systems / Control algorithms / Cross-Over Studies / Diabetes / Diabetes mellitus (insulin dependent) / Diabetes Mellitus, Type 1 - drug therapy / Endocrinology / Endocrinology General / Equipment Design / Female / Glucose / Glycated Hemoglobin A - analysis / Glycemic Control - instrumentation / Glycemic Control - methods / Hemoglobin / Humans / Hyperglycemia - diagnosis / Hypoglycemia / Hypoglycemic Agents - administration & dosage / Infant / Insulin / Insulin - administration & dosage / Insulin Infusion Systems / Male / Pancreas / Pancreas, Artificial / Pediatrics / Pediatrics General / Sensors / Smartphones / Standard deviation

2022

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Randomized Trial of Closed-Loop Control in Very Young Children with Type 1 Diabetes

2022

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Randomized Trial of Closed-Loop Control in Very Young Children with Type 1 Diabetes

2022

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Journal Article

Randomized Trial of Closed-Loop Control in Very Young Children with Type 1 Diabetes

Thankamony, Ajay,

Hovorka, Roman,

Boughton, Charlotte K,

Lawton, Julia,

Kapellen, Thomas M,

Campbell, Fiona M,

Yong, James,

Hood, Korey K,

Roze, Stephane,

Fröhlich-Reiterer, Elke,

Sibayan, Judy,

Schierloh, Ulrike,

de Beaufort, Carine,

Nagl, Katrin,

Hartnell, Sara,

Hofer, Sabine E,

Tauschmann, Martin,

Kollman, Craig,

Wilinska, Malgorzata E,

Ware, Julia,

Mader, Julia K,

Bocchino, Laura E,

Allen, Janet M,

Rami-Merhar, Birgit

2022

Overview

In a multicenter, randomized, crossover trial involving children 1 to 7 years of age with type 1 diabetes, a closed-loop system was compared with sensor-augmented pump therapy in random order. The closed-loop system improved glycemic control in very young children with type 1 diabetes, without increasing the time spent in a hypoglycemic state.

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Publisher

Massachusetts Medical Society

Subject

Adverse events

/ Age groups

/ Algorithms

/ Blood Glucose - analysis

/ Caregivers

/ Child

/ Child, Preschool