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Vadadustat in Patients with Anemia and Non–Dialysis-Dependent CKD

by Roy-Chaudhury, Prabir , Parfrey, Patrick S , Bako, Gabriel , Sharma, Amit , Chertow, Glenn M , Lin, Tim , Tseng, Carol , Farag, Youssef M.K , Sarnak, Mark J , Agarwal, Rajiv , Castillo, Fausto P , Vargo, Dennis L , Eckardt, Kai-Uwe , Matsushita, Kunihiro , Winkelmayer, Wolfgang C , Jardine, Alan G , Tumlin, James , McCullough, Peter A , Arnold, Susan , Maroni, Bradley J , Koury, Mark J , Wittes, Janet , Block, Geoffrey A , Spinowitz, Bruce , Burke, Steven , Pergola, Pablo E , Walters, Kimberly A , Khawaja, Zeeshan , Lewis, Eldrin F , Luo, Wenli

in Administration, Oral / Aged / Anemia / Anemia - blood / Anemia - drug therapy / Anemia - etiology / Cardiovascular Diseases - chemically induced / Cerebral infarction / Clinical trials / Collaboration / Confidence intervals / Congestive heart failure / Darbepoetin alfa - adverse effects / Darbepoetin alfa - therapeutic use / Design / Dialysis / Drug dosages / Erythropoiesis / Erythropoietin / Female / Glycine - adverse effects / Glycine - analogs & derivatives / Glycine - therapeutic use / Heart attacks / Heart failure / Hematinics - adverse effects / Hematinics - therapeutic use / Hemodialysis / Hemoglobin / Hemoglobins - analysis / Hospitalization - statistics & numerical data / Humans / Hydroxylase / Hypoxia / Hypoxia-inducible factors / Kidney diseases / Male / Middle Aged / Myocardial infarction / Patients / Picolinic Acids - adverse effects / Picolinic Acids - therapeutic use / Prolyl hydroxylase / Prolyl-Hydroxylase Inhibitors - adverse effects / Prolyl-Hydroxylase Inhibitors - therapeutic use / Renal Insufficiency, Chronic - complications / Renal Insufficiency, Chronic - mortality / Safety / Thromboembolism

2021

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Vadadustat in Patients with Anemia and Non–Dialysis-Dependent CKD

2021

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2021

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Journal Article

Vadadustat in Patients with Anemia and Non–Dialysis-Dependent CKD

Roy-Chaudhury, Prabir,

Parfrey, Patrick S,

Bako, Gabriel,

Sharma, Amit,

Chertow, Glenn M,

Lin, Tim,

Tseng, Carol,

Farag, Youssef M.K,

Sarnak, Mark J,

Agarwal, Rajiv,

Castillo, Fausto P,

Vargo, Dennis L,

Eckardt, Kai-Uwe,

Matsushita, Kunihiro,

Winkelmayer, Wolfgang C,

Jardine, Alan G,

Tumlin, James,

McCullough, Peter A,

Arnold, Susan,

Maroni, Bradley J,

Koury, Mark J,

Wittes, Janet,

Block, Geoffrey A,

Spinowitz, Bruce,

Burke, Steven,

Pergola, Pablo E,

Walters, Kimberly A,

Khawaja, Zeeshan,

Lewis, Eldrin F,

Luo, Wenli

2021

Overview

Two randomized, phase 3, open-label noninferiority trials compared vadadustat with darbepoetin alfa in patients with non–dialysis-dependent chronic kidney disease. Vadadustat, as compared with darbepoetin alfa, met the prespecified noninferiority criterion for hematologic efficacy but not for cardiovascular safety.

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Publisher

Massachusetts Medical Society

Subject

Administration, Oral

/ Aged

/ Anemia

/ Anemia - blood

/ Anemia - drug therapy

/ Anemia - etiology

/ Cardiovascular Diseases - chemically induced