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Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer
by
Shapira-Frommer, Ronnie
, Arkhipov, Alexander
, Colombo, Nicoletta
, Monk, Bradley J
, Li, Kan
, Salman, Pamela
, Dubot, Coraline
, Samouëlian, Vanessa
, Castonguay, Vincent
, Caceres, M. Valeria
, Yañez, Eduardo
, Olivera Hurtado de Mendoza, Mivael
, Toker, Sarper
, Hoyos Usta, Edwin
, Tewari, Krishnansu S
, Gümüş, Mahmut
, Hasegawa, Kosei
, Keefe, Stephen M
, Lorusso, Domenica
in
Adult
/ Adverse events
/ Aged
/ Aged, 80 and over
/ Antibodies, Monoclonal, Humanized - adverse effects
/ Antibodies, Monoclonal, Humanized - therapeutic use
/ Antineoplastic Agents, Immunological - adverse effects
/ Antineoplastic Agents, Immunological - therapeutic use
/ Apoptosis
/ Bevacizumab
/ Cancer therapies
/ Carcinoma - drug therapy
/ Carcinoma - mortality
/ Carcinoma - secondary
/ Cervical cancer
/ Cervix
/ Chemotherapy
/ Death
/ Double-Blind Method
/ Female
/ Gynecologic Oncology
/ Gynecology
/ Hematology
/ Humans
/ Hypotheses
/ Immunotherapy
/ Intention to Treat Analysis
/ Laboratories
/ Metastases
/ Metastasis
/ Middle Aged
/ Monoclonal antibodies
/ Neoplasm Staging
/ Neutropenia
/ Obstetrics
/ Oncology
/ Patient Reported Outcome Measures
/ Patients
/ PD-L1 protein
/ Pembrolizumab
/ Placebos
/ Progression-Free Survival
/ Radiation therapy
/ Statistical analysis
/ Survival Analysis
/ Targeted cancer therapy
/ Treatments in Oncology
/ Tumor cells
/ Tumors
/ Uterine Cervical Neoplasms - drug therapy
/ Uterine Cervical Neoplasms - mortality
/ Uterine Cervical Neoplasms - pathology
2021
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Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer
by
Shapira-Frommer, Ronnie
, Arkhipov, Alexander
, Colombo, Nicoletta
, Monk, Bradley J
, Li, Kan
, Salman, Pamela
, Dubot, Coraline
, Samouëlian, Vanessa
, Castonguay, Vincent
, Caceres, M. Valeria
, Yañez, Eduardo
, Olivera Hurtado de Mendoza, Mivael
, Toker, Sarper
, Hoyos Usta, Edwin
, Tewari, Krishnansu S
, Gümüş, Mahmut
, Hasegawa, Kosei
, Keefe, Stephen M
, Lorusso, Domenica
in
Adult
/ Adverse events
/ Aged
/ Aged, 80 and over
/ Antibodies, Monoclonal, Humanized - adverse effects
/ Antibodies, Monoclonal, Humanized - therapeutic use
/ Antineoplastic Agents, Immunological - adverse effects
/ Antineoplastic Agents, Immunological - therapeutic use
/ Apoptosis
/ Bevacizumab
/ Cancer therapies
/ Carcinoma - drug therapy
/ Carcinoma - mortality
/ Carcinoma - secondary
/ Cervical cancer
/ Cervix
/ Chemotherapy
/ Death
/ Double-Blind Method
/ Female
/ Gynecologic Oncology
/ Gynecology
/ Hematology
/ Humans
/ Hypotheses
/ Immunotherapy
/ Intention to Treat Analysis
/ Laboratories
/ Metastases
/ Metastasis
/ Middle Aged
/ Monoclonal antibodies
/ Neoplasm Staging
/ Neutropenia
/ Obstetrics
/ Oncology
/ Patient Reported Outcome Measures
/ Patients
/ PD-L1 protein
/ Pembrolizumab
/ Placebos
/ Progression-Free Survival
/ Radiation therapy
/ Statistical analysis
/ Survival Analysis
/ Targeted cancer therapy
/ Treatments in Oncology
/ Tumor cells
/ Tumors
/ Uterine Cervical Neoplasms - drug therapy
/ Uterine Cervical Neoplasms - mortality
/ Uterine Cervical Neoplasms - pathology
2021
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Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer
by
Shapira-Frommer, Ronnie
, Arkhipov, Alexander
, Colombo, Nicoletta
, Monk, Bradley J
, Li, Kan
, Salman, Pamela
, Dubot, Coraline
, Samouëlian, Vanessa
, Castonguay, Vincent
, Caceres, M. Valeria
, Yañez, Eduardo
, Olivera Hurtado de Mendoza, Mivael
, Toker, Sarper
, Hoyos Usta, Edwin
, Tewari, Krishnansu S
, Gümüş, Mahmut
, Hasegawa, Kosei
, Keefe, Stephen M
, Lorusso, Domenica
in
Adult
/ Adverse events
/ Aged
/ Aged, 80 and over
/ Antibodies, Monoclonal, Humanized - adverse effects
/ Antibodies, Monoclonal, Humanized - therapeutic use
/ Antineoplastic Agents, Immunological - adverse effects
/ Antineoplastic Agents, Immunological - therapeutic use
/ Apoptosis
/ Bevacizumab
/ Cancer therapies
/ Carcinoma - drug therapy
/ Carcinoma - mortality
/ Carcinoma - secondary
/ Cervical cancer
/ Cervix
/ Chemotherapy
/ Death
/ Double-Blind Method
/ Female
/ Gynecologic Oncology
/ Gynecology
/ Hematology
/ Humans
/ Hypotheses
/ Immunotherapy
/ Intention to Treat Analysis
/ Laboratories
/ Metastases
/ Metastasis
/ Middle Aged
/ Monoclonal antibodies
/ Neoplasm Staging
/ Neutropenia
/ Obstetrics
/ Oncology
/ Patient Reported Outcome Measures
/ Patients
/ PD-L1 protein
/ Pembrolizumab
/ Placebos
/ Progression-Free Survival
/ Radiation therapy
/ Statistical analysis
/ Survival Analysis
/ Targeted cancer therapy
/ Treatments in Oncology
/ Tumor cells
/ Tumors
/ Uterine Cervical Neoplasms - drug therapy
/ Uterine Cervical Neoplasms - mortality
/ Uterine Cervical Neoplasms - pathology
2021
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Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer
Journal Article
Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer
2021
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Overview
A randomized, double-blind trial compared pembrolizumab with placebo in patients with advanced cervical cancer who were also receiving platinum-based chemotherapy with or without bevacizumab. The median progression-free survival was 10.4 months with pembrolizumab and 8.2 months with placebo. Overall survival at 2 years was 50.4% and 40.4%, respectively.
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Antibodies, Monoclonal, Humanized - adverse effects
/ Antibodies, Monoclonal, Humanized - therapeutic use
/ Antineoplastic Agents, Immunological - adverse effects
/ Antineoplastic Agents, Immunological - therapeutic use
/ Cervix
/ Death
/ Female
/ Humans
/ Oncology
/ Patient Reported Outcome Measures
/ Patients
/ Placebos
/ Tumors
/ Uterine Cervical Neoplasms - drug therapy
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