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Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents

by Venâncio da Cunha, Rivaldo , Bravo, Lulu , Brose, Manja , Wallace, Derek , Borkowski, Astrid , Dietze, Reynaldo , LeFevre, Inge , Biswal, Shibadas , López-Medina, Eduardo , Sirivichayakul, Chukiat , Watanaveeradej, Veerachai , Espinoza, Felix , Kosalaraksa, Pope , Rivera, Luis , Saez-Llorens, Xavier , Bizjajeva, Svetlana , Reynales, Humberto , Borja-Tabora, Charissa , Luz, Kleber , Jimeno, José , Rauscher, Martina , Lopez, Pio , Fernando, LakKumar

in Adolescent / Adolescents / Age / Americas - epidemiology / Antibodies, Neutralizing - blood / Antibodies, Viral - blood / Asia - epidemiology / Child / Child, Preschool / Children / Childrens health / Clinical outcomes / Clinical trials / Dengue - epidemiology / Dengue - immunology / Dengue - prevention & control / Dengue fever / Dengue Vaccines - adverse effects / Dengue Vaccines - immunology / Dengue Virus - immunology / Dengue Virus - isolation & purification / Double-Blind Method / Endemic Diseases - prevention & control / Evidence-based medicine / Female / Hospitalization / Humans / Incidence / Infections / Male / Parents & parenting / Polymerase chain reaction / Serogroup / Side effects / Surveillance / Technical communication / Teenagers / Treatment Outcome / Tropical diseases / Vaccine efficacy / Vaccines / Viral diseases / Viruses

2019

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Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents

2019

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2019

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Journal Article

Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents

Venâncio da Cunha, Rivaldo,

Bravo, Lulu,

Brose, Manja,

Wallace, Derek,

Borkowski, Astrid,

Dietze, Reynaldo,

LeFevre, Inge,

Biswal, Shibadas,

López-Medina, Eduardo,

Sirivichayakul, Chukiat,

Watanaveeradej, Veerachai,

Espinoza, Felix,

Kosalaraksa, Pope,

Rivera, Luis,

Saez-Llorens, Xavier,

Bizjajeva, Svetlana,

Reynales, Humberto,

Borja-Tabora, Charissa,

Luz, Kleber,

Jimeno, José,

Rauscher, Martina,

Lopez, Pio,

Fernando, LakKumar

2019

Overview

It is estimated that there are 390 million cases of dengue virus infection each year. In this double-blind, placebo-controlled trial, a tetravalent dengue vaccine was evaluated in 20,071 children. The vaccine was found to be 80% effective in preventing dengue infection.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adolescents

/ Age

/ Americas - epidemiology

/ Antibodies, Neutralizing - blood

/ Antibodies, Viral - blood

/ Asia - epidemiology