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Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A

by von Drygalski, Annette , Weyand, Angela C. , Nogami, Keiji , Poloskey, Stacey , Susen, Sophie , Oldenburg, Johannes , Willemze, Annemieke , Kulkarni, Roshni , Winding, Bent , Chowdary, Pratima , Knobe, Karin , Klamroth, Robert , Matino, Davide , Konkle, Barbara A. , Jimenez-Yuste, Victor

in Bleeding / Body weight / Chemoprevention / Childhood Diseases / Coagulants - administration & dosage / Coagulants - therapeutic use / Coagulation / Coagulation factors / Disease prevention / Drug Administration Schedule / Factor VIII - administration & dosage / Factor VIII - therapeutic use / Genetics / Genetics General / Half-Life / Hematology / Hemophilia / Hemophilia A - complications / Hemophilia A - drug therapy / Hemorrhage - drug therapy / Hemorrhage - etiology / Hemorrhage - prevention & control / Humans / Life Sciences / Oncology / Pain / Patients / Pediatrics / Pharmacokinetics / Population studies / Prophylaxis / Quality of life / Recombinant Fusion Proteins - administration & dosage / Recombinant Fusion Proteins - therapeutic use / Surgery / Von Willebrand factor / von Willebrand Factor - administration & dosage / von Willebrand Factor - therapeutic use

2023

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2023

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Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A

2023

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Journal Article

Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A

von Drygalski, Annette,

Weyand, Angela C.,

Nogami, Keiji,

Poloskey, Stacey,

Susen, Sophie,

Oldenburg, Johannes,

Willemze, Annemieke,

Kulkarni, Roshni,

Winding, Bent,

Chowdary, Pratima,

Knobe, Karin,

Klamroth, Robert,

Matino, Davide,

Konkle, Barbara A.,

Jimenez-Yuste, Victor

2023

Overview

Efanesoctocog alfa is a factor VIII fusion agent that permits weekly treatment to prevent bleeding. In this study, two thirds of treated patients had no bleeding episodes, and the annualized bleeding rate fell by 77%.

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Publisher

Massachusetts Medical Society

Subject

/ Coagulants - administration & dosage

/ Coagulants - therapeutic use

/ Coagulation