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Exposure to prenatal maternal distress and infant white matter neurodevelopment
by
Davis, Elysia Poggi
, Garcia, Sarah E.
, Hankin, Benjamin L.
, Bagonis, Maria M.
, Gilmore, John H.
, Styner, Martin A.
, Demers, Catherine H.
, Al-Ali, Khalid
, Hoffman, M. Camille
in
Anisotropy
/ Anxiety
/ Brain
/ Brain - pathology
/ Brain research
/ Cell division
/ Diffusion tensor imaging
/ Diffusion Tensor Imaging - methods
/ Emotional regulation
/ Female
/ Fetuses
/ Gestation
/ Gestational age
/ Health status
/ Humans
/ Infant
/ Infants
/ Influence
/ Longitudinal Studies
/ Magnetic resonance imaging
/ Maternal and infant welfare
/ Maternal characteristics
/ Maternal distress
/ Mental depression
/ Mental health
/ Mothers
/ Neuroimaging
/ Pregnancy
/ Prenatal care
/ Prenatal experience
/ Prenatal exposure
/ Prospective Studies
/ Psychological distress
/ Psychopathology
/ Stress
/ Substantia alba
/ White Matter - diagnostic imaging
2021
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Exposure to prenatal maternal distress and infant white matter neurodevelopment
by
Davis, Elysia Poggi
, Garcia, Sarah E.
, Hankin, Benjamin L.
, Bagonis, Maria M.
, Gilmore, John H.
, Styner, Martin A.
, Demers, Catherine H.
, Al-Ali, Khalid
, Hoffman, M. Camille
in
Anisotropy
/ Anxiety
/ Brain
/ Brain - pathology
/ Brain research
/ Cell division
/ Diffusion tensor imaging
/ Diffusion Tensor Imaging - methods
/ Emotional regulation
/ Female
/ Fetuses
/ Gestation
/ Gestational age
/ Health status
/ Humans
/ Infant
/ Infants
/ Influence
/ Longitudinal Studies
/ Magnetic resonance imaging
/ Maternal and infant welfare
/ Maternal characteristics
/ Maternal distress
/ Mental depression
/ Mental health
/ Mothers
/ Neuroimaging
/ Pregnancy
/ Prenatal care
/ Prenatal experience
/ Prenatal exposure
/ Prospective Studies
/ Psychological distress
/ Psychopathology
/ Stress
/ Substantia alba
/ White Matter - diagnostic imaging
2021
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Exposure to prenatal maternal distress and infant white matter neurodevelopment
by
Davis, Elysia Poggi
, Garcia, Sarah E.
, Hankin, Benjamin L.
, Bagonis, Maria M.
, Gilmore, John H.
, Styner, Martin A.
, Demers, Catherine H.
, Al-Ali, Khalid
, Hoffman, M. Camille
in
Anisotropy
/ Anxiety
/ Brain
/ Brain - pathology
/ Brain research
/ Cell division
/ Diffusion tensor imaging
/ Diffusion Tensor Imaging - methods
/ Emotional regulation
/ Female
/ Fetuses
/ Gestation
/ Gestational age
/ Health status
/ Humans
/ Infant
/ Infants
/ Influence
/ Longitudinal Studies
/ Magnetic resonance imaging
/ Maternal and infant welfare
/ Maternal characteristics
/ Maternal distress
/ Mental depression
/ Mental health
/ Mothers
/ Neuroimaging
/ Pregnancy
/ Prenatal care
/ Prenatal experience
/ Prenatal exposure
/ Prospective Studies
/ Psychological distress
/ Psychopathology
/ Stress
/ Substantia alba
/ White Matter - diagnostic imaging
2021
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Exposure to prenatal maternal distress and infant white matter neurodevelopment
Journal Article
Exposure to prenatal maternal distress and infant white matter neurodevelopment
2021
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Overview
The prenatal period represents a critical time for brain growth and development. These rapid neurological advances render the fetus susceptible to various influences with life-long implications for mental health. Maternal distress signals are a dominant early life influence, contributing to birth outcomes and risk for offspring psychopathology. This prospective longitudinal study evaluated the association between prenatal maternal distress and infant white matter microstructure. Participants included a racially and socioeconomically diverse sample of 85 mother–infant dyads. Prenatal distress was assessed at 17 and 29 weeks’ gestational age (GA). Infant structural data were collected via diffusion tensor imaging (DTI) at 42–45 weeks’ postconceptional age. Findings demonstrated that higher prenatal maternal distress at 29 weeks’ GA was associated with increased fractional anisotropy,
b
= .283,
t
(64) = 2.319,
p
= .024, and with increased axial diffusivity,
b
= .254,
t
(64) = 2.067,
p
= .043, within the right anterior cingulate white matter tract. No other significant associations were found with prenatal distress exposure and tract fractional anisotropy or axial diffusivity at 29 weeks’ GA, or earlier in gestation.
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