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Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation

by Schutzman, Jennifer L. , Patel, Manish R. , Chang, Julie , Krebs, Matthew G. , Mandlekar, Sandhya , Miller, Wilson H. , Falcon, Alejandro , Desai, Jayesh , Dharia, Neekesh V. , Arbour, Kathryn , Lin, Mark T. , Bowyer, Samantha , Choi, Yoonha , Sacher, Adrian , de Miguel, Maria , Lee, Jong-Seok , Shi, Zhen , Paz-Ares, Luis , LoRusso, Patricia , Santoro, Armando , Garralda, Elena , Forster, Martin D. , Massarelli, Erminia , Han, Sae-Won , Royer-Joo, Stephanie , Kim, Tae Won , Cheng, Michael L.

in Administration, Oral / Adverse events / Antineoplastic Agents / Antineoplastic Agents - administration & dosage / Antineoplastic Agents - adverse effects / Antineoplastic Agents - therapeutic use / Antitumor activity / Biopsy / Cancer / Cancer therapies / Carcinoma, Non-Small-Cell Lung / Carcinoma, Non-Small-Cell Lung - drug therapy / Carcinoma, Non-Small-Cell Lung - genetics / Colorectal cancer / Colorectal carcinoma / Colorectal Neoplasms / Colorectal Neoplasms - drug therapy / Colorectal Neoplasms - genetics / Confidence intervals / Critical Care / Critical Care General / Enrollments / Enzyme Inhibitors / Enzyme Inhibitors - administration & dosage / Enzyme Inhibitors - adverse effects / Enzyme Inhibitors - therapeutic use / Gastroenterology / Gastrointestinal Tract Cancer / Gene frequency / General Medicine / Genetics / Hematology / Hematology/Oncology / Human health sciences / Humans / K-Ras protein / KRAS protein, human / Lung Cancer / Lung Neoplasms / Lung Neoplasms - drug therapy / Lung Neoplasms - genetics / Medicine (all) / Metastases / Metastasis / Mutation / Nervous system / Non-small cell lung carcinoma / Oncologie / Oncology / Oral administration / Patients / Pharmacokinetics / Proteins / Proto-Oncogene Proteins p21(ras) / Proto-Oncogene Proteins p21(ras) - genetics / Pulmonary / Pulmonary/Critical Care / Pulmonary/Critical Care General / Sciences de la santé humaine / Small cell lung carcinoma / Solid tumors / Treatments in Oncology / Tumors

2023

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Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation

2023

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Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation

2023

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Journal Article

Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation

Schutzman, Jennifer L.,

Patel, Manish R.,

Chang, Julie,

Krebs, Matthew G.,

Mandlekar, Sandhya,

Miller, Wilson H.,

Falcon, Alejandro,

Desai, Jayesh,

Dharia, Neekesh V.,

Arbour, Kathryn,

Lin, Mark T.,

Bowyer, Samantha,

Choi, Yoonha,

Sacher, Adrian,

de Miguel, Maria,

Lee, Jong-Seok,

Shi, Zhen,

Paz-Ares, Luis,

LoRusso, Patricia,

Santoro, Armando,

Garralda, Elena,

Forster, Martin D.,

Massarelli, Erminia,

Han, Sae-Won,

Royer-Joo, Stephanie,

Kim, Tae Won,

Cheng, Michael L.

2023

Overview

Among patients with cancers bearing the KRAS G12C mutation who received divarasib at a 400-mg dose, 56% with lung cancer, 36% with colorectal cancer, and 36% with other tumor types had a confirmed response.

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Publisher

Massachusetts Medical Society,Massachussetts Medical Society

Subject

Administration, Oral

/ Adverse events

/ Antineoplastic Agents

/ Antineoplastic Agents - administration & dosage

/ Antineoplastic Agents - adverse effects

/ Antineoplastic Agents - therapeutic use

/ Antitumor activity