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Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
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Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
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Journal Article
Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
2016
Overview
Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4
+
T cells in mouse skin are in equilibrium with the circulation at steady state. These cells are dispersed throughout the inter-follicular regions of the dermis and form clusters with antigen presenting cells around hair follicles. After infection or administration of a contact sensitizing agent, there is a sustained increase in skin CD4
+
T-cell content, which is confined to the clusters, with a concomitant CCL5-dependent increase in CD4
+
T-cell recruitment. Skin CCL5 is derived from CD11b
+
cells and CD8
+
T cells, with the elimination of the latter decreasing CD4
+
T-cell numbers. These results reveal a complex pattern of tissue-retention and equilibration for CD4
+
memory T cells in skin, which is altered by infection and inflammation history.
Memory T cells are vital responders to skin inflammation, but cell localization and dynamics of exchange with the bloodstream are not clear. Here the authors use parabiosis and intravital microscopy to show that CD4
+
memory T cells equilibrate with the circulation and cluster around hair follicles in response to CCL5-dependent responses to viral infection or contact sensitization.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/31
/ 14/19
/ 14/69
/ 692/308
/ Abdomen
/ Adult
/ Animals
/ Antigen-Presenting Cells - cytology
/ Antigen-Presenting Cells - immunology
/ Antigens
/ CD4-Positive T-Lymphocytes - cytology
/ CD4-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - immunology
/ Cell Aggregation - immunology
/ Cells
/ Female
/ Humanities and Social Sciences
/ Humans
/ Interferon-gamma - biosynthesis
/ Mice
/ Science
/ Skin
