Asset Details
Do you wish to reserve the book?
Exploiting functional regions in the viral RNA genome as druggable entities
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Exploiting functional regions in the viral RNA genome as druggable entities
Do you wish to request the book?
Exploiting functional regions in the viral RNA genome as druggable entities
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Exploiting functional regions in the viral RNA genome as druggable entities
2025
Overview
RNA-targeting compounds or small interfering RNAs (siRNAs) offer a potent means to control viral infections. An essential prerequisite for their design depends on identifying conserved and functional viral RNA structures in cells. Techniques that probe RNA structures in situ have recently been developed including SHAPE-MaP, which has been helpful in the analysis of secondary structures of RNA. In this study, we report on the application of SHAPE-MaP to the porcine epidemic diarrhea virus RNA genome to categorize different functional regions, including potential quadruplex-forming sequence and target sites of siRNA. Our results show that these structures can be exploited to inhibit viral proliferation and that SHAPE-MaP is an effective method to identify secondary structures in RNA genomes.
Publisher
eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd
Subject
/ Antiviral Agents - pharmacology
/ Biochemistry and Chemical Biology
/ Diarrhea
/ Entropy
/ Genomes
/ Mutation
/ Porcine epidemic diarrhea virus - drug effects
/ Porcine epidemic diarrhea virus - genetics
/ RNA
/ RNA, Small Interfering - genetics
/ RNA, Small Interfering - metabolism
/ siRNA
/ Swine
