Asset Details
Do you wish to reserve the book?
IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity
Do you wish to request the book?
IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity
2015
Overview
Environmental signals can be translated into chromatin changes, which alter gene expression. Here we report a novel concept that cells can signal chromatin damage from the nucleus back to the surrounding tissue through the cytokine interleukin-1alpha (IL-1α). Thus, in addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, IL-1α could directly sense DNA damage and act as signal for genotoxic stress without loss of cell integrity. Here we demonstrate localization of the cytokine to DNA-damage sites and its subsequent secretion. Interestingly, its nucleo-cytosolic shuttling after DNA damage sensing is regulated by histone deacetylases (HDAC) and IL-1α acetylation. To demonstrate the physiological significance of this newly discovered mechanism, we used IL-1α knockout mice and show that IL-1α signaling after UV skin irradiation and DNA damage is important for triggering a sterile inflammatory cascade
in vivo
that contributes to efficient tissue repair and wound healing.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/51
/ 14/19
/ 14/63
/ 38/90
/ 631/250
/ 64/60
/ 82/58
/ Animals
/ Biochemistry, Molecular Biology
/ DNA Damage - radiation effects
/ Histone Deacetylases - metabolism
/ Humanities and Social Sciences
/ Humans
/ Immunity, Innate - physiology
/ Interleukin-1alpha - genetics
/ Interleukin-1alpha - metabolism
/ Recombinant Proteins - genetics
/ Recombinant Proteins - metabolism
/ Science
