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GPRC5D-Targeted CAR T Cells for Myeloma

by Landa, Jonathan , Cadzin, Briana , Rivière, Isabelle , Giralt, Sergio A. , Mead, Elena , Brentjens, Renier J. , Hassoun, Hani , Park, Jae H. , Shah, Urvi A. , Hultcrantz, Malin , Farzana, Tasmin , Shah, Gunjan L. , Roshal, Mikhail , Devlin, Sean M. , Fitzgerald, Lisa , Bermudez, Vladimir P. , Tan, Carlyn R. , Dogan, Ahmet , Sen, Filiz , Nath, Karthik , Purdon, Terence J. , Russo, Douglas , Mailankody, Sham , Korde, Neha , Carstens, Elizabeth J. , Diamonte, Claudia , Landgren, Ola , Lesokhin, Alexander , Usmani, Saad Z. , Senechal, Brigitte , Hosszu, Kinga , Auclair, Romany , Wilcox, Jessica A. , Santomasso, Bianca D. , Sikder, Devanjan , Wang, Xiuyan , McAvoy, Devin P. , Smith, Eric L.

in Antibodies / Antigens / Apheresis / B-Cell Maturation Antigen - therapeutic use / Bone marrow / Cell therapy / Cerebellum / Chimeric antigen receptors / Consent / Cytokine Release Syndrome - etiology / Cytokines / Drug dosages / Hematology / Humans / Immunotherapy / Immunotherapy, Adoptive - adverse effects / Immunotherapy, Adoptive - methods / Leukemia / Lymphocytes / Lymphocytes B / Lymphocytes T / Lymphoma / Multiple myeloma / Multiple Myeloma - drug therapy / Neoplasm Recurrence, Local - etiology / Neurotoxicity / Oncology / Patients / Proteins / Receptors, Chimeric Antigen - therapeutic use / Receptors, G-Protein-Coupled - therapeutic use / T-Lymphocytes / Treatments in Oncology

2022

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2022

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2022

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Journal Article

GPRC5D-Targeted CAR T Cells for Myeloma

Landa, Jonathan,

Cadzin, Briana,

Rivière, Isabelle,

Giralt, Sergio A.,

Mead, Elena,

Brentjens, Renier J.,

Hassoun, Hani,

Park, Jae H.,

Shah, Urvi A.,

Hultcrantz, Malin,

Farzana, Tasmin,

Shah, Gunjan L.,

Roshal, Mikhail,

Devlin, Sean M.,

Fitzgerald, Lisa,

Bermudez, Vladimir P.,

Tan, Carlyn R.,

Dogan, Ahmet,

Sen, Filiz,

Nath, Karthik,

Purdon, Terence J.,

Russo, Douglas,

Mailankody, Sham,

Korde, Neha,

Carstens, Elizabeth J.,

Diamonte, Claudia,

Landgren, Ola,

Lesokhin, Alexander,

Usmani, Saad Z.,

Senechal, Brigitte,

Hosszu, Kinga,

Auclair, Romany,

Wilcox, Jessica A.,

Santomasso, Bianca D.,

Sikder, Devanjan,

Wang, Xiuyan,

McAvoy, Devin P.,

Smith, Eric L.

2022

Overview

In an early-phase study involving 17 patients with highly refractory multiple myeloma, CAR T-cell therapy with specificity for a G protein–coupled receptor that is expressed on myeloma cells produced a response in 71% of the patients.

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Publisher

Massachusetts Medical Society

Subject

Antibodies

/ Antigens

/ Apheresis

/ B-Cell Maturation Antigen - therapeutic use

/ Bone marrow

/ Cell therapy

/ Cerebellum