Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53

by Gundem, Gunes , Horwitz, Steven M. , Eren, Ozgur Can , Arcila, Maria E. , Mitra, Sneha , Everett, John K. , Scordo, Michael , Giralt, Sergio A. , Domenico, Dylan , Leslie, Christina , Park, Jae H. , Borsu, Laetitia , Patel, Ruchi , Shah, Gunjan L. , Dogan, Ahmet , Bushman, Frederic D. , Perica, Karlo , Papaemmanuil, Elli , Patel, Utsav , Mailankody, Sham , Jain, Nayan , Socci, Nicholas D. , Usmani, Saad Z. , Roche, Aoife M. , Petrichenko, Angelina , Sadelain, Michel

in Aged / Antigens / B-Cell Maturation Antigen - genetics / B-Cell Maturation Antigen - immunology / Biopsy / Cancer therapies / Case reports / CD4 antigen / CD4-Positive T-Lymphocytes - immunology / Cell therapy / Cell Transformation, Neoplastic - genetics / Cell Transformation, Neoplastic - immunology / Cells / Chimeric antigen receptors / Cloning / Cytokines / Diarrhea / Fatal Outcome / Female / Genes / Genomes / Hematology / Humans / Immunotherapy, Adoptive - adverse effects / Immunotherapy, Adoptive - methods / Integration / Kinases / Lentivirus - genetics / Leukemia / Lymphocytes / Lymphocytes B / Lymphocytes T / Lymphoma / Lymphoma, T-Cell - diagnosis / Lymphoma, T-Cell - genetics / Lymphoma, T-Cell - immunology / Lymphoma, T-Cell - pathology / Multiple myeloma / Multiple Myeloma - complications / Multiple Myeloma - immunology / Multiple Myeloma - therapy / Mutation / Oncology / Proteins / Receptors, Chimeric Antigen - genetics / Receptors, Chimeric Antigen - immunology / T-cell lymphoma / Treatments in Oncology / Tumor suppressor genes / Tumor Suppressor Protein p53 - genetics / Tumorigenesis

2025

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53

2025

Confirm

Do you wish to request the book?

CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53

2025

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53

Gundem, Gunes,

Horwitz, Steven M.,

Eren, Ozgur Can,

Arcila, Maria E.,

Mitra, Sneha,

Everett, John K.,

Scordo, Michael,

Giralt, Sergio A.,

Domenico, Dylan,

Leslie, Christina,

Park, Jae H.,

Borsu, Laetitia,

Patel, Ruchi,

Shah, Gunjan L.,

Dogan, Ahmet,

Bushman, Frederic D.,

Perica, Karlo,

Papaemmanuil, Elli,

Patel, Utsav,

Mailankody, Sham,

Jain, Nayan,

Socci, Nicholas D.,

Usmani, Saad Z.,

Roche, Aoife M.,

Petrichenko, Angelina,

Sadelain, Michel

2025

Overview

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case of a T-cell lymphoma harboring a lentiviral integration in a known tumor suppressor, TP53 , which developed in a patient with multiple myeloma after B-cell maturation antigen (BCMA) CAR T-cell therapy. A woman with multiply relapsed multiple myeloma had complete remission with cilta-cel, but a low-grade T-cell lymphoma soon developed in the GI tract that contained an insertion of the CAR construct disrupting expression of p53.

Share this book

Add to My Shelf

Publisher

Massachusetts Medical Society

Subject

Aged

/ Antigens

/ B-Cell Maturation Antigen - genetics

/ B-Cell Maturation Antigen - immunology

/ Biopsy

/ Cancer therapies

/ Case reports