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Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants

by Takas, Therese , Khan, Anis A , Simões, Eric A.F , Yuan, Yuan , Madhi, Shabir A , DeVincenzo, John P , Manzoni, Paolo , Domachowske, Joseph B , Dubovsky, Filip , Esser, Mark T , Griffin, M. Pamela , Villafana, Tonya

in Antibodies / Antibodies, Monoclonal - administration & dosage / Antibodies, Monoclonal - adverse effects / Antibodies, Monoclonal, Humanized - administration & dosage / Antibodies, Monoclonal, Humanized - adverse effects / Antiviral Agents - administration & dosage / Antiviral Agents - adverse effects / Disease prevention / FDA approval / Female / Gestation / Gestational age / Health care / Hospitalization / Hospitalization - statistics & numerical data / Humans / Hypersensitivity / Incidence / Infant / Infant, Newborn / Infant, Premature / Infants / Infections / Injections, Intramuscular / Kaplan-Meier Estimate / Laboratories / Life Sciences / Male / Monoclonal antibodies / Newborn babies / Pharmacokinetics / Poisson Distribution / Premature babies / Respiratory diseases / Respiratory syncytial virus / Respiratory Syncytial Virus Infections - epidemiology / Respiratory Syncytial Virus Infections - prevention & control / Respiratory Syncytial Virus, Human / Respiratory tract diseases / Respiratory Tract Infections - epidemiology / Respiratory Tract Infections - prevention & control / Respiratory Tract Infections - virology / Vaccines / Viral Fusion Proteins - antagonists & inhibitors / Vitamin E / Writers

2020

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2020

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2020

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Journal Article

Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants

Takas, Therese,

Khan, Anis A,

Simões, Eric A.F,

Yuan, Yuan,

Madhi, Shabir A,

DeVincenzo, John P,

Manzoni, Paolo,

Domachowske, Joseph B,

Dubovsky, Filip,

Esser, Mark T,

Griffin, M. Pamela,

Villafana, Tonya

2020

Overview

Nirsevimab, a monoclonal antibody with an extended half-life, is designed to protect infants from respiratory syncytial virus disease after a single intramuscular dose. This placebo-controlled trial involving 1447 preterm infants at 164 sites in 23 countries assessed the effectiveness of nirsevimab over 150 days after the dose was administered.

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Publisher

Massachusetts Medical Society

Subject

Antibodies

/ Antibodies, Monoclonal - administration & dosage

/ Antibodies, Monoclonal - adverse effects

/ Antibodies, Monoclonal, Humanized - administration & dosage

/ Antibodies, Monoclonal, Humanized - adverse effects

/ Antiviral Agents - administration & dosage

/ Antiviral Agents - adverse effects