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Trial of Pimavanserin in Dementia-Related Psychosis

by McEvoy, Bradley , Ballard, Clive , Soto-Martin, Maria E , Weintraub, Daniel , Devanand, Davangere P , Youakim, James M , Foff, Erin P , Tariot, Pierre N , Erten-Lyons, Deniz , Stankovic, Srdjan , Cummings, Jeffrey L , Sultzer, David L

in Adverse events / Aged / Aged, 80 and over / Aging / Alzheimer Disease / Alzheimer's disease / Antipsychotic Agents - therapeutic use / Antipsychotics / Clinical Practice / Clinical trials / Constipation / Dementia / Dementia - drug therapy / Dementia - psychology / Dementia disorders / Double-Blind Method / Drug dosages / Female / Frontotemporal dementia / Geriatrics / Hallucinations / Hallucinations - drug therapy / Hallucinations - etiology / Hospitalist / Humans / Hydrogen / Inverse agonists / Kaplan-Meier Estimate / Lewy bodies / Life Sciences / Male / Middle Aged / Movement disorders / Neurodegenerative diseases / Neurology / Neurosurgery / Neurosurgery General / Parkinson Disease - drug therapy / Parkinson Disease - psychology / Parkinson's disease / Patients / Piperidines - therapeutic use / Placebos / Primary Care / Proportional Hazards Models / Psychiatry / Psychiatry General / Psychosis / Psychotic Disorders - drug therapy / Psychotic Disorders - etiology / Psychotropic drugs / Recurrence / Serotonin S2 receptors / Urea - analogs & derivatives / Urea - therapeutic use / Urinary tract / Vascular dementia / Withdrawal

2021

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2021

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2021

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Journal Article

Trial of Pimavanserin in Dementia-Related Psychosis

McEvoy, Bradley,

Ballard, Clive,

Soto-Martin, Maria E,

Weintraub, Daniel,

Devanand, Davangere P,

Youakim, James M,

Foff, Erin P,

Tariot, Pierre N,

Erten-Lyons, Deniz,

Stankovic, Srdjan,

Cummings, Jeffrey L,

Sultzer, David L

2021

Overview

The serotonin-receptor modulator pimavanserin reduces psychosis in patients with Parkinson’s disease. In a randomized discontinuation trial involving patients with psychosis related to several types of dementia, the frequency of relapse over a period of 26 weeks was 13% with pimavanserin and 28% with placebo.

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Publisher

Massachusetts Medical Society

Subject

Adverse events

/ Aged

/ Aged, 80 and over

/ Aging

/ Alzheimer Disease

/ Alzheimer's disease

/ Antipsychotic Agents - therapeutic use