Asset Details
Do you wish to reserve the book?
Circulating Bile Acids as Biomarkers for Disease Diagnosis and Prevention
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Circulating Bile Acids as Biomarkers for Disease Diagnosis and Prevention
Do you wish to request the book?
Circulating Bile Acids as Biomarkers for Disease Diagnosis and Prevention
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Circulating Bile Acids as Biomarkers for Disease Diagnosis and Prevention
2023
Overview
ContextBile acids (BAs) are pivotal signaling molecules that regulate energy metabolism and inflammation. Recent epidemiological studies have reported specific alterations in circulating BA profiles in certain disease states, including obesity, type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD), and Alzheimer disease (AD). In the past decade, breakthroughs have been made regarding the translation of BA profiling into clinical use for disease prediction. In this review, we summarize and synthesize recent data on variation in circulating BA profiles in patients with various diseases to evaluate the value of these biomarkers in human plasma for early diagnosis.
Evidence AcquisitionThis review is based on a collection of primary and review literature gathered from a PubMed search for BAs, obesity, T2DM, insulin resistance (IR), NAFLD, hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), colon cancer, and AD, among other keywords.
Evidence SynthesisIndividuals with obesity, T2DM, HCC, CCA, or AD showed specific alterations in circulating BA profiles. These alterations may have existed long before the initial diagnosis of these diseases. The intricate relationship between obesity, IR, and NAFLD complicates the establishment of clear and independent associations between BA profiles and nonalcoholic steatohepatitis. Alterations in the levels of total BAs and several BA species were seen across the entire spectrum of NAFLD, demonstrating significant increases with the worsening of histological features.
ConclusionsAberrant circulating BA profiles are an early event in the onset and progression of obesity, T2DM, HCC, and AD. The pleiotropic effects of BAs explain these broad connections. Circulating BA profiles could provide a basis for the development of biomarkers for the diagnosis and prevention of a wide range of diseases.
Publisher
Oxford University Press
Subject
/ Bile Acids and Salts - blood
/ Bile Acids and Salts - chemistry
/ Carcinoma, Hepatocellular - diagnosis
/ Carcinoma, Hepatocellular - etiology
/ Diabetes mellitus (non-insulin dependent)
/ Diabetes Mellitus, Type 2 - metabolism
/ Disease
/ Humans
/ Insulin
/ Liver
/ Non-alcoholic Fatty Liver Disease - diagnosis
/ Non-alcoholic Fatty Liver Disease - etiology
/ Obesity
