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Germacrone, isolated from Curcuma wenyujin, inhibits melanin synthesis through the regulation of the MAPK signaling pathway
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Germacrone, isolated from Curcuma wenyujin, inhibits melanin synthesis through the regulation of the MAPK signaling pathway
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Journal Article
Germacrone, isolated from Curcuma wenyujin, inhibits melanin synthesis through the regulation of the MAPK signaling pathway
2024
Overview
Abnormal melanin synthesis causes hyperpigmentation disorders, such as chloasma, freckles, and melanoma, which are highly multiple and prevalent. There were few reports on the anti-melanogenic effect of
Curcuma wenyujin
Y.H. Chen et C. Ling, and the bioactive compound has not been elucidated as well. The study aims to investigate the anti-melanogenic effect of
C. wenyujin
, and identify the bioactive compound, and further explore its underlying mechanism. Our results showed that the Petroleum ether fraction extracted from
C. wenyujin
rhizome had a significant anti-melanogenic effect, and germacrone isolated from it was confirmed as the major bioactive compound. To our data, germacrone significantly inhibited tyrosinase (TYR) activity, reduced melanosome synthesis, reduced dendrites formation of B16F10 cells, and melanosome transport to keratinocytes. Moreover, germacrone effectively decreased the hyperpigmentation in zebrafish and the skin of guinea pigs in vivo. Western-blot analysis showed that germacrone down-regulated the expression of TYR, TRP-1, TRP-2, Rab27a, Cdc42, and MITF proteins via the activation of the MAPK signaling pathway. Taken together, germacrone is an effective bioactive compound for melanogenesis inhibition. Our studies suggest that germacrone may be considered a potential candidate for skin whitening.
Graphical abstract
Publisher
Springer Nature Singapore,Springer Nature B.V
Subject
/ Animals
/ Biomedical and Life Sciences
/ Complementary & Alternative Medicine
/ Curcuma
/ Kinases
/ MAP Kinase Signaling System - drug effects
/ Melanin
/ Melanoma
/ Mice
/ Monophenol Monooxygenase - antagonists & inhibitors
/ Monophenol Monooxygenase - metabolism
/ Pharmacy
/ Proteins
/ Rhizomes
/ Sesquiterpenes, Germacrane - chemistry
/ Sesquiterpenes, Germacrane - pharmacology
