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Host resistance factor SLC11A1 restricts Salmonella growth through magnesium deprivation
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Host resistance factor SLC11A1 restricts Salmonella growth through magnesium deprivation
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Journal Article
Host resistance factor SLC11A1 restricts Salmonella growth through magnesium deprivation
2019
Overview
The pleiotropic host resistance factor SLC11A1 (NRAMP1) defends against diverse intracellular pathogens in mammals by yet-unknown mechanisms. We compared Salmonella infection of coisogenic mice with different SLC11A1 alleles. SLC11A1 reduced Salmonella replication and triggered up-regulation of uptake systems for divalent metal cations but no other stress responses. SLC11A1 modestly diminished iron availability and acutely restricted Salmonella access to magnesium. Growth of Salmonella cells in the presence of SLC11A1 was highly heterogeneous and inversely correlated with expression of the crucial magnesium transporter gene mgtB. We observed superimposable single-cell patterns in mice lacking SLC11A1 when we restricted Salmonella access to magnesium by impairing its uptake. Together, these findings identify deprivation of the main group metal magnesium as the main resistance mechanism of SLC11A1 against Salmonella.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science,American Association for the Advancement of Science (AAAS)
Subject
Adenosine Triphosphatases - metabolism
/ Alleles
/ Animals
/ Bacteria
/ Bacterial Proteins - metabolism
/ Cation Transport Proteins - genetics
/ Cation Transport Proteins - metabolism
/ Cations
/ Disease Resistance - genetics
/ Mammals
/ Mice
/ Microbiology and Parasitology
/ Mutation
/ Proteome
/ Salmonella Infections, Animal - metabolism
/ Salmonella Infections, Animal - microbiology
/ Salmonella typhimurium - genetics
/ Salmonella typhimurium - growth & development
/ Salmonella typhimurium - metabolism
