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Rumination-focused cognitive–behavioural therapy for residual depression: phase II randomised controlled trial
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Rumination-focused cognitive–behavioural therapy for residual depression: phase II randomised controlled trial
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Journal Article
Rumination-focused cognitive–behavioural therapy for residual depression: phase II randomised controlled trial
2011
Overview
About 20% of major depressive episodes become chronic and medication-refractory and also appear to be less responsive to standard cognitive-behavioural therapy (CBT).
To test whether CBT developed from behavioural activation principles that explicitly and exclusively targets depressive rumination enhances treatment as usual (TAU) in reducing residual depression.
Forty-two consecutively recruited participants meeting criteria for medication-refractory residual depression were randomly allocated to TAU v. TAU plus up to 12 sessions of individual rumination-focused CBT. The trial has been registered (ISRCTN22782150).
Adding rumination-focused CBT to TAU significantly improved residual symptoms and remission rates. Treatment effects were mediated by change in rumination.
This is the first randomised controlled trial providing evidence of benefits of rumination-focused CBT in persistent depression. Although suggesting the internal validity of rumination-focused CBT for residual depression, the trial lacked an attentional control group so cannot test whether the effects were as a result of the specific content of rumination-focused CBT v. non-specific therapy effects.
Publisher
Cambridge University Press
Subject
/ Adult
/ Anxiety Disorders - epidemiology
/ Anxiety Disorders - psychology
/ Cognitive behavioral therapy
/ Cognitive-behavioral factors
/ Depressive Disorder, Major - epidemiology
/ Depressive Disorder, Major - psychology
/ Depressive Disorder, Major - therapy
/ Depressive Disorder, Treatment-Resistant - epidemiology
/ Depressive Disorder, Treatment-Resistant - psychology
/ Depressive Disorder, Treatment-Resistant - therapy
/ Drugs
/ Female
/ Humans
/ Male
/ Psychiatric Status Rating Scales
/ Therapy
/ Thinking
