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Role of fibroblast growth factor receptor 4 in cancer
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Journal Article
Role of fibroblast growth factor receptor 4 in cancer
2018
Overview
Fibroblast growth factor receptors (FGFR) play a significant role in both embryonic development and in adults. Upon binding with ligands, FGFR signaling is activated and triggers various downstream signal cascades that are implicated in diverse biological processes. Aberrant regulations of FGFR signaling are detected in numerous cancers. Although FGFR4 was discovered later than other FGFR, information on the involvement of FGFR4 in cancers has significantly increased in recent years. In this review, the recent findings in FGFR4 structure, signaling transduction, physiological function, aberrant regulations, and effects in cancers as well as its potential applications as an anticancer therapeutic target are summarized.
FGFR4 dysregulation in cancers and crystal structures of the FGFR4 codon 535 and 550 mutations.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ Antineoplastic Agents - pharmacology
/ Antineoplastic Agents - therapeutic use
/ cancer
/ Fibroblast growth factor receptor 4
/ Fibroblast growth factor receptors
/ Fibroblast Growth Factors - metabolism
/ Humans
/ Kinases
/ Ligands
/ Molecular Targeted Therapy - methods
/ Mutation
/ Peptides
/ Polymorphism, Single Nucleotide
/ Proteins
/ Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors
/ Receptor, Fibroblast Growth Factor, Type 4 - chemistry
/ Receptor, Fibroblast Growth Factor, Type 4 - genetics
/ Receptor, Fibroblast Growth Factor, Type 4 - metabolism
/ Review
/ RNA, Small Interfering - therapeutic use
/ Signal Transduction - drug effects
