Journal Article

Longitudinal association of atopic dermatitis progression and keratin 6A

Margolis, David J., Mitra, Nandita, Zhu, Angela Y.

2022

Overview

Atopic dermatitis is a common skin disease characterized by loss of skin integrity. Risk and severity have been associated with genetic variation especially with respect to the filaggrin gene, suggesting the importance of skin barrier function in atopic dermatitis pathogenesis. The keratin protein plays a role in epithelial health but its relationship with disease severity would benefit from further exploration. In this study, we evaluate the association between common keratin 6 variants and severity of atopic dermatitis over time using a Bayesian generalized linear mixed model to account for repeated measures. We identify groups of variants within which individual variants have similar effects on skin repair. Further assessment of the biological mechanisms by which these contribute to repair of epidermis may inform treatment of atopic dermatitis.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 631/208/205 / 639/705/531 / 692/699/4033 / Atopic dermatitis / Bayes Theorem / Bayesian analysis / Dermatitis / Dermatitis, Atopic - pathology / Eczema / Epidermis / Erythema / Filaggrin / Genes / Genetic diversity / Genetic Predisposition to Disease / Humanities and Social Sciences / Humans / Inflammatory diseases / Intermediate Filament Proteins - genetics / Intermediate Filament Proteins - metabolism / Keratin / Keratin-6 - genetics / multidisciplinary / Mutation / Proteins / Psoriasis / Science / Science (multidisciplinary) / Skin - metabolism / Skin diseases