Asset Details
Do you wish to reserve the book?
A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function
Do you wish to request the book?
A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function
2012
Overview
The pivalate moiety of some oral antibiotics enhances their intestinal absorption, but liberated pivalic acid decreases tissue carnitine concentration and could lead to impaired energy metabolism. The present study investigated the effects of short-term sodium pivalate administration on cardiac functionality and mitochondrial energy metabolism. Wistar rats received sodium pivalate (40 mM) in their drinking water for 14 days, and the carnitine content was measured in heart tissues. The activities of carnitine-dependent enzymes, including carnitine acetyltransferase (CrAT) and carnitine palmitoyltransferase I (CPT I), and the mitochondrial respiration rate were also measured. The isolated rat heart ischemia–reperfusion injury assay was performed based on the Langendorff technique through the reversible occlusion of the left anterior descending coronary artery. The administration of sodium pivalate decreased carnitine concentration in the myocardium by 37 %. Sodium pivalate significantly decreased mitochondrial respiration on pyruvate/malate by 28 %. The activities of CrAT and CPT I in sodium pivalate-treated animals were decreased by 34 and 30 %, respectively. No differences were observed in the infarct size or in the heart functional parameters between the groups. Together, these results indicate that the short-term administration of a high dose of sodium pivalate impairs cardiac mitochondrial energy metabolism without depressing cardiac function during ischemia–reperfusion injury.
Publisher
Humana Press Inc,Springer,Springer Nature B.V
Subject
/ Animals
/ Biomedical and Life Sciences
/ carnitine palmitoyltransferase
/ Energy
/ Energy Metabolism - drug effects
/ Energy Metabolism - physiology
/ Enzymes
/ Heart
/ Injuries
/ Ischemia
/ Male
/ Mitochondria, Heart - drug effects
/ Mitochondria, Heart - physiology
/ Myocardial Reperfusion Injury - metabolism
/ Myocardial Reperfusion Injury - physiopathology
/ Pentanoic Acids - administration & dosage
/ Pyruvic Acid - antagonists & inhibitors
/ Rats
/ Sodium
