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Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents

by Heidemann, Sabrina M , Boom, Julie A , Irby, Katherine , Hobbs, Charlotte V , Sahni, Leila C , Gertz, Shira J , Flori, Heidi R , Chiotos, Kathleen , Cvijanovich, Natalie Z , Zinter, Matt S , Pannaraj, Pia S , Gaspers, Mary G , Schwartz, Stephanie P , Kamidani, Satoshi , Zambrano, Laura D , Mack, Elizabeth H , Schuster, Jennifer E , Maddux, Aline B , Nofziger, Ryan A , Levy, Emily R , Randolph, Adrienne G , Cameron, Melissa A , Campbell, Angela P , Bhumbra, Samina S , Bline, Katherine E , Hume, Janet R , Halasa, Natasha B , Staat, Mary A , Olson, Samantha M , Patel, Manish M , Newhams, Margaret M , Michelson, Kelly N , Walker, Tracie C , Cullimore, Melissa L , Bradford, Tamara T , Price, Ashley M , Maamari, Mia , Kong, Michele , Chatani, Brandon M

in Adolescence / Adolescent / Adolescent Medicine / Adolescents / BNT162 Vaccine / Case-Control Studies / Child / Coronavirus / Coronaviruses / COVID-19 / COVID-19 - mortality / COVID-19 - prevention & control / COVID-19 - therapy / COVID-19 Testing / COVID-19 Vaccines / Female / Hospitalization - statistics & numerical data / Humans / Immunization / Immunization, Secondary / Infectious Disease / Intensive Care Units / Life Support Care / Male / Mechanical ventilation / mRNA / Multisystem inflammatory syndrome in children / Original / Oxygenation / Patient Acuity / Patients / Pediatrics / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Teenagers / United States / Vaccination / Vaccine Efficacy / Vaccines

2022

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Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents

2022

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2022

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Journal Article

Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents

Heidemann, Sabrina M,

Boom, Julie A,

Irby, Katherine,

Hobbs, Charlotte V,

Sahni, Leila C,

Gertz, Shira J,

Flori, Heidi R,

Chiotos, Kathleen,

Cvijanovich, Natalie Z,

Zinter, Matt S,

Pannaraj, Pia S,

Gaspers, Mary G,

Schwartz, Stephanie P,

Kamidani, Satoshi,

Zambrano, Laura D,

Mack, Elizabeth H,

Schuster, Jennifer E,

Maddux, Aline B,

Nofziger, Ryan A,

Levy, Emily R,

Randolph, Adrienne G,

Cameron, Melissa A,

Campbell, Angela P,

Bhumbra, Samina S,

Bline, Katherine E,

Hume, Janet R,

Halasa, Natasha B,

Staat, Mary A,

Olson, Samantha M,

Patel, Manish M,

Newhams, Margaret M,

Michelson, Kelly N,

Walker, Tracie C,

Cullimore, Melissa L,

Bradford, Tamara T,

Price, Ashley M,

Maamari, Mia,

Kong, Michele,

Chatani, Brandon M

2022

Overview

Investigators used a case–control, test-negative design to assess the effectiveness of the BNT162b2 vaccine in adolescents for the prevention of Covid-19–related hospitalization, ICU admission, or receipt of life support. Among 445 case patients and 777 controls, of the 180 patients admitted to an ICU, only 2 had been fully vaccinated; all 7 deaths occurred in unvaccinated patients.

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Publisher

Massachusetts Medical Society

Subject

Adolescence

/ Adolescent

/ Adolescent Medicine

/ Adolescents

/ BNT162 Vaccine

/ Case-Control Studies

/ Child