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Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)
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Journal Article
Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)
2020
Overview
Flavonoids are natural biomolecules that are known to be effective antivirals. These biomolecules can act at different stages of viral infection, particularly at the molecular level to inhibit viral growth. Enterovirus A71 (EV-A71), a non-enveloped RNA virus, is one of the causative agents of hand, foot and mouth disease (HFMD), which is prevalent in Asia. Despite much effort, no clinically approved antiviral treatment is available for children suffering from HFMD. Flavonoids from plants serve as a vast reservoir of therapeutically active constituents that have been explored as potential antiviral candidates against RNA and DNA viruses. Here, we reviewed flavonoids as evidence-based natural sources of antivirals against non-picornaviruses and picornaviruses. The detailed molecular mechanisms involved in the inhibition of EV-A71 infections are discussed.
Publisher
MDPI,MDPI AG
Subject
/ Antiviral Agents - pharmacology
/ Asia
/ Biological Products - pharmacology
/ Child
/ children
/ Enterovirus A, Human - drug effects
/ Enterovirus A, Human - physiology
/ hand, foot and mouth disease
/ hand, foot and mouth disease (hfmd)
/ Hand, Foot and Mouth Disease - drug therapy
/ Hand, Foot and Mouth Disease - virology
/ Humans
/ infectious childhood disease
/ Mice
/ Review
/ RNA
/ Virus Replication - drug effects
/ viruses
