Asset Details
Do you wish to reserve the book?
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases
Do you wish to request the book?
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases
2022
Overview
Both mitochondrial dysfunction and neuroinflammation are implicated in neurodegeneration and neurodegenerative diseases. Accumulating evidence shows multiple links between mitochondrial dysfunction and neuroinflammation. Mitochondrial-derived damage-associated molecular patterns (DAMPs) are recognized by immune receptors of microglia and aggravate neuroinflammation. On the other hand, inflammatory factors released by activated glial cells trigger an intracellular cascade, which regulates mitochondrial metabolism and function. The crosstalk between mitochondrial dysfunction and neuroinflammatory activation is a complex and dynamic process. There is strong evidence that mitochondrial dysfunction precedes neuroinflammation during the progression of diseases. Thus, an in-depth understanding of the specific molecular mechanisms associated with mitochondrial dysfunction and the progression of neuroinflammation in neurodegenerative diseases may contribute to the identification of new targets for the treatment of diseases. In this review, we describe in detail the DAMPs that induce or aggravate neuroinflammation in neurodegenerative diseases including mtDNA, mitochondrial unfolded protein response (mtUPR), mitochondrial reactive oxygen species (mtROS), adenosine triphosphate (ATP), transcription factor A mitochondria (TFAM), cardiolipin, cytochrome
c
, mitochondrial Ca
2+
and iron.
Publisher
Springer Nature Singapore,Nature Publishing Group
Subject
/ Adenosine Triphosphate - metabolism
/ Biomedical and Life Sciences
/ DNA, Mitochondrial - genetics
/ DNA, Mitochondrial - metabolism
/ Humans
/ Neurodegenerative Diseases - metabolism
/ Neuroinflammatory Diseases - metabolism
/ Reactive Oxygen Species - metabolism
/ Review
/ Transcription Factors - metabolism
/ Vaccine
