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Alcohol consumption in the general population is associated with structural changes in multiple organ systems
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Journal Article
Alcohol consumption in the general population is associated with structural changes in multiple organ systems
2021
Overview
Excessive alcohol consumption is associated with damage to various organs, but its multi-organ effects have not been characterised across the usual range of alcohol drinking in a large general population sample.
We assessed global effect sizes of alcohol consumption on quantitative magnetic resonance imaging phenotypic measures of the brain, heart, aorta, and liver of UK Biobank participants who reported drinking alcohol.
We found a monotonic association of higher alcohol consumption with lower normalised brain volume across the range of alcohol intakes (-1.7 × 10
± 0.76 × 10
per doubling of alcohol consumption, p=3.0 × 10
). Alcohol consumption was also associated directly with measures of left ventricular mass index and left ventricular and atrial volume indices. Liver fat increased by a mean of 0.15% per doubling of alcohol consumption.
Our results imply that there is not a 'safe threshold' below which there are no toxic effects of alcohol. Current public health guidelines concerning alcohol consumption may need to be revisited.
See acknowledgements.
Publisher
eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd
Subject
/ Alcohol Drinking - adverse effects
/ Alcohol Drinking - epidemiology
/ Alcohol-Induced Disorders - diagnostic imaging
/ Alcohol-Induced Disorders - epidemiology
/ Aorta
/ Biobanks
/ brain
/ Brain Diseases - diagnostic imaging
/ Brain Diseases - epidemiology
/ Cardiomyopathy, Alcoholic - diagnostic imaging
/ Cardiomyopathy, Alcoholic - epidemiology
/ Diabetes
/ Epidemiology and Global Health
/ Fatty Liver, Alcoholic - diagnostic imaging
/ Fatty Liver, Alcoholic - epidemiology
/ Female
/ Heart
/ Humans
/ imaging
/ Liver
/ Male
