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Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis
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Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis
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Journal Article
Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis
2024
Overview
Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal progenitors that can contribute to muscle tissue homeostasis and regeneration, as well as postnatal maturation and lifelong maintenance of the neuromuscular system. Recently, traumatic injury to the peripheral nerve was shown to activate FAPs, suggesting that FAPs can respond to nerve injury. However, questions of how FAPs can sense the anatomically distant peripheral nerve injury and whether FAPs can directly contribute to nerve regeneration remained unanswered. Here, utilizing single-cell transcriptomics and mouse models, we discovered that a subset of FAPs expressing GDNF receptors
Ret
and
Gfra1
can respond to peripheral nerve injury by sensing GDNF secreted by Schwann cells. Upon GDNF sensing, this subset becomes activated and expresses
Bdnf
. FAP-specific inactivation of
Bdnf
(
Prrx1
Cre
; Bdnf
fl/fl
) resulted in delayed nerve regeneration owing to defective remyelination, indicating that GDNF-sensing FAPs play an important role in the remyelination process during peripheral nerve regeneration. In aged mice, significantly reduced
Bdnf
expression in FAPs was observed upon nerve injury, suggesting the clinical relevance of FAP-derived BDNF in the age-related delays in nerve regeneration. Collectively, our study revealed the previously unidentified role of FAPs in peripheral nerve regeneration, and the molecular mechanism behind FAPs’ response to peripheral nerve injury.
Publisher
eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd
Subject
/ Animals
/ BDNF
/ Brain-derived neurotrophic factor
/ Brain-Derived Neurotrophic Factor - metabolism
/ GDNF
/ Glial cell line-derived neurotrophic factor
/ Glial Cell Line-Derived Neurotrophic Factor - genetics
/ Glial Cell Line-Derived Neurotrophic Factor - metabolism
/ Glial Cell Line-Derived Neurotrophic Factor Receptors - genetics
/ Glial Cell Line-Derived Neurotrophic Factor Receptors - metabolism
/ Male
/ Mesenchymal Stem Cells - metabolism
/ Mice
/ Peripheral Nerve Injuries - metabolism
/ Proto-Oncogene Proteins c-ret - genetics
/ Proto-Oncogene Proteins c-ret - metabolism
