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Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma

by Chmiel, James F , Sheehan, William J , Bacharier, Leonard B , Benson, Mindy , Baxi, Sachin N , Gaffin, Jonathan M , Boehmer, Susan J , Szefler, Stanley J , Raissy, Hengameh H , Phipatanakul, Wanda , Pongracic, Jacqueline A , Robison, Rachel G , Holguin, Fernando , Gentile, Deborah A , Cabana, Michael D , Mauger, David T , Martinez, Fernando D , Lazarus, Stephen C , Daines, Cori L , Thyne, Shannon M , Covar, Ronina , Lemanske, Robert F , Beigelman, Avraham , Morgan, Wayne J , Ly, Ngoc , Jackson, Daniel J , Israel, Elliot , Olin, J. Tod , Daines, Michael O , Blake, Kathryn , Kumar, Harsha V , Wechsler, Michael E , Gower, W. Adam , Lang, Jason E , Ross, Kristie , Paul, Ian M , Lima, John J , Sorkness, Christine A , Myers, Ross E , Marbin, Jyothi , Moy, James N , Peters, Stephen P , Fitzpatrick, Anne M

in Acetaminophen / Acetaminophen - adverse effects / Acetaminophen - therapeutic use / Analgesics / Aspirin / Asthma / Asthma - chemically induced / Asthma - epidemiology / Child, Preschool / Children / Children & youth / Double-Blind Method / Female / Fever / Fever - drug therapy / Glucocorticoids / Health risk assessment / Humans / Ibuprofen / Ibuprofen - adverse effects / Ibuprofen - therapeutic use / Incidence / Infant / Kaplan-Meier Estimate / Male / Pain / Pain - drug therapy / Pediatrics / Prospective Studies

2016

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Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma

2016

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2016

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Journal Article

Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma

Chmiel, James F,

Sheehan, William J,

Bacharier, Leonard B,

Benson, Mindy,

Baxi, Sachin N,

Gaffin, Jonathan M,

Boehmer, Susan J,

Szefler, Stanley J,

Raissy, Hengameh H,

Phipatanakul, Wanda,

Pongracic, Jacqueline A,

Robison, Rachel G,

Holguin, Fernando,

Gentile, Deborah A,

Cabana, Michael D,

Mauger, David T,

Martinez, Fernando D,

Lazarus, Stephen C,

Daines, Cori L,

Thyne, Shannon M,

Covar, Ronina,

Lemanske, Robert F,

Beigelman, Avraham,

Morgan, Wayne J,

Ly, Ngoc,

Jackson, Daniel J,

Israel, Elliot,

Olin, J. Tod,

Daines, Michael O,

Blake, Kathryn,

Kumar, Harsha V,

Wechsler, Michael E,

Gower, W. Adam,

Lang, Jason E,

Ross, Kristie,

Paul, Ian M,

Lima, John J,

Sorkness, Christine A,

Myers, Ross E,

Marbin, Jyothi,

Moy, James N,

Peters, Stephen P,

Fitzpatrick, Anne M

2016

Overview

There has been concern that acetaminophen may exacerbate asthma. These investigators found no difference in asthma control among young children treated for minor illnesses with acetaminophen as compared with ibuprofen. Many children younger than 12 years of age receive acetaminophen each week, making it the most commonly used pediatric medication in the United States. 1 Observational data from both pediatric and adult cohorts have suggested an association between acetaminophen use and concurrent asthma symptoms and decreased lung function. 2 – 6 Furthermore, a post hoc analysis of a randomized trial on the safety of short-term use of acetaminophen versus ibuprofen for febrile illnesses in children similarly showed that the relative risk of unscheduled visits for asthma after the use of acetaminophen was substantially higher than the risk after the use of ibuprofen. 7 These . . .

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Publisher

Massachusetts Medical Society

Subject

Acetaminophen

/ Acetaminophen - adverse effects

/ Acetaminophen - therapeutic use

/ Analgesics

/ Aspirin

/ Asthma

/ Asthma - chemically induced