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An Update on Vitamin D Metabolism
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Journal Article
An Update on Vitamin D Metabolism
2020
Overview
Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1α-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review. Moreover, in the last decades, several extraskeletal effects which can be attributed to vitamin D have been shown. These beneficial effects will be here summarized, focusing on the immune system and cardiovascular system.
Publisher
MDPI AG,MDPI
Subject
25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism
/ Animals
/ COVID-19
/ Cytochrome P-450 Enzyme System - metabolism
/ Cytochrome P450 Family 2 - metabolism
/ Enzymes
/ Genomes
/ Humans
/ Kinases
/ Mixed Function Oxygenases - metabolism
/ Mutation
/ Proteins
/ Receptors, Calcitriol - metabolism
/ Review
/ Skin
