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Thrombocytopenia in patients with Plasmodium vivax in Colombia is associated with anti-phosphatidylserine autoantibodies and IL-6, IFNγ, IL-10 and TGF-β
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Thrombocytopenia in patients with Plasmodium vivax in Colombia is associated with anti-phosphatidylserine autoantibodies and IL-6, IFNγ, IL-10 and TGF-β
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Thrombocytopenia in patients with Plasmodium vivax in Colombia is associated with anti-phosphatidylserine autoantibodies and IL-6, IFNγ, IL-10 and TGF-β
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Journal Article
Thrombocytopenia in patients with Plasmodium vivax in Colombia is associated with anti-phosphatidylserine autoantibodies and IL-6, IFNγ, IL-10 and TGF-β
2025
Overview
Plasmodium vivax is the most widely distributed human protozoan in the world. It is a causative agent of malaria, with thrombocytopenia being a frequent complication. This study aimed to evaluate the effect of P. vivax infection on plasma cytokine/chemokine levels and anti-phosphatidylserine (anti-PS) autoantibodies, to explore their potential role in thrombocytopenia during P. vivax malaria in Córdoba, Colombia. We included patients with P. vivax malaria and thrombocytopenia (MT); patients with malaria without thrombocytopenia (M) and healthy controls (HC). Plasma cytokines/chemokines (IL-2, IL-4, IL-1β, TNF-α, IL-17A, IL-6, IL-10, IFNγ, IL-12p70, TGF-β1/IP-10, MCP-1, IL-8) were quantified. Evaluation of autoantibodies was performed by ELISA, using phosphatidylserine (PS) as the antigen. IFNγ, IL-6, and IL-10 were found to increase in the MT group (P < 0.05), whereas TGF-β1 was increased in the M group (P < 0.0001). Anti-PS antibody levels were also higher in the MT group and showed a negative correlation with platelet counts. These findings suggest that thrombocytopenia in P. vivax malaria may result from autoantibodies targeting phosphatidylserine on activated platelets, driven by a pro-inflammatory cytokine imbalance, with TGF-β1 potentially exerting a protective effect.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Adult
/ Aged
/ Anemia
/ Blood
/ Female
/ Humans
/ Malaria
/ Malaria, Vivax - complications
/ Male
/ Medicine and Health Sciences
/ Monocyte chemoattractant protein 1
/ Phosphatidylserines - immunology
/ Plasmodium vivax - immunology
/ Thrombocytopenia - immunology
/ Thrombocytopenia - parasitology
/ Transforming Growth Factor beta - blood
/ Transforming growth factor-b
