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Investigating dynamics, etiology, pathology, and therapeutic interventions of Caligus clemensi and Vibrio alginolyticus co-infection in farmed marine fish
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Investigating dynamics, etiology, pathology, and therapeutic interventions of Caligus clemensi and Vibrio alginolyticus co-infection in farmed marine fish
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Journal Article
Investigating dynamics, etiology, pathology, and therapeutic interventions of Caligus clemensi and Vibrio alginolyticus co-infection in farmed marine fish
2024
Overview
This study investigated a disease outbreak characterized by caligid copepod infestations and subsequent secondary bacterial infections in European seabass (
Dicentrarchus labrax
) and flathead grey mullet (
Mugil cephalus
) cultivated at a private facility in the Deeba Triangle region of Egypt. Moribund fish displayed brown spots on the skin, tongue, and gills, along with lethargy and excess mucus. The fish suffered severe infections, exhibiting external hemorrhages, ulcers, and ascites. The fish had pale, enlarged livers with hemorrhaging. Comprehensive parasitological, bacteriological, molecular, immunity and histopathological analyses were conducted to identify the etiological agents and pathological changes. Caligid copepod infestation was observed in wet mounts from the buccal and branchial cavities of all examined fish, and the caligids were identified as
Caligus clemensi
through
COI
gene sequencing and phylogenetic analysis.
Vibrio alginolyticus
was confirmed as a secondary bacterial infection through biochemical tests,
recA
gene sequencing, and phylogenetic analyses. Antibiotic susceptibility testing revealed resistance to β-lactams, aminoglycosides, and trimethoprim-sulfamethoxazole in
V. alginolyticus
isolates. Upregulation of the inflammatory marker
IL-1β
in gill and skin tissues indicated a robust cell-mediated immune response against the pathogens. Histopathological examination revealed severe tissue damage, hyperplasia, hemorrhage, and congestion in the gills, along with hepatocellular degeneration and steatosis in the liver, providing initial insights into this outbreak. A comprehensive therapeutic regimen was implemented, comprising prolonged hydrogen peroxide immersion baths, followed by the application of the nature-identical plant-based compound Lice-less and probiotic Sanolife Pro-W supplementation. This integrated approach effectively eliminated
C. clemensi
infestations, controlled secondary bacterial infections, and restored fish health, reducing morbidity and mortality rates to minimal levels.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/326
/ Animals
/ Ascites
/ Bacteria
/ Fish Diseases - microbiology
/ Gills
/ Humanities and Social Sciences
/ Immune response (cell-mediated)
/ Science
/ Trimethoprim-sulfamethoxazole
/ Ulcers
/ Vibrio alginolyticus - pathogenicity
/ Vibrio alginolyticus - physiology
/ Vibrio Infections - drug therapy
/ Vibrio Infections - microbiology
