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Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
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Journal Article
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
2022
Overview
Host genetics are known to influence the gut microbiome, yet their role remains poorly understood. To robustly characterize these effects, we performed a genome-wide association study of 207 taxa and 205 pathways representing microbial composition and function in 7,738 participants of the Dutch Microbiome Project. Two robust, study-wide significant (
P
< 1.89 × 10
−10
) signals near the
LCT
and
ABO
genes were found to be associated with multiple microbial taxa and pathways and were replicated in two independent cohorts. The
LCT
locus associations seemed modulated by lactose intake, whereas those at
ABO
could be explained by participant secretor status determined by their
FUT2
genotype. Twenty-two other loci showed suggestive evidence (
P
< 5 × 10
−8
) of association with microbial taxa and pathways. At a more lenient threshold, the number of loci we identified strongly correlated with trait heritability, suggesting that much larger sample sizes are needed to elucidate the remaining effects of host genetics on the gut microbiome.
A genome-wide association study of 207 taxa and 205 pathways representing gut microbial composition and function from 7,738 individuals of the Dutch Microbiome Project identifies genetic associations at the
LCT
and
ABO
loci.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ ABO Blood-Group System - genetics
/ Animal Genetics and Genomics
/ Bacterial Physiological Phenomena
/ Bifidobacterium - physiology
/ Biomedical and Life Sciences
/ Diet
/ Fucosyltransferases - genetics
/ Galactoside 2-alpha-L-fucosyltransferase
/ Gastrointestinal Tract - microbiology
/ Genetics
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Humans
/ Lactose
/ Metabolic Networks and Pathways
