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Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

by Fernández-Silva, Patricio , Perales-Clemente, Ester , Moreno-Loshuertos, Raquel , Balsa, Eduardo , Quirós, Pedro M. , Calvo, Enrique , Acín-Pérez, Rebeca , Rodríguez-Hernández, M. A. , Navas, Plácido , Carracedo, Ángel , López-Otín, Carlos , Latorre-Pellicer, Ana , Cruz, Raquel , Colás, Carmen , Lapuente-Brun, Esther , Pérez-Martos, Acisclo , Fernández-Vizarra, Erika , Enríquez, José Antonio

in Amino Acid Sequence / Animals / Cell lines / Cells, Cultured / Cellular immunity / Cytochromes c - metabolism / Electron Transport / electron transport chain / Electron Transport Complex I - genetics / Electron Transport Complex I - metabolism / Electron Transport Complex III - genetics / Electron Transport Complex III - metabolism / Electron Transport Complex IV - genetics / Electron Transport Complex IV - metabolism / Electrons / energy / Enzymes / Fibroblasts / Gene Knockdown Techniques / HEK293 Cells / Humans / Liver mitochondria / Metabolism / Mice / Mice, Inbred C57BL / Mitochondria / Mitochondria - enzymology / Molecular biology / Molecular Sequence Data / Proteins / Redox reactions / Respiration / Respiratory mechanics / Ubiquinone - metabolism

2013

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Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

2013

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Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

2013

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Journal Article

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

Fernández-Silva, Patricio,

Perales-Clemente, Ester,

Moreno-Loshuertos, Raquel,

Balsa, Eduardo,

Quirós, Pedro M.,

Calvo, Enrique,

Acín-Pérez, Rebeca,

Rodríguez-Hernández, M. A.,

Navas, Plácido,

Carracedo, Ángel,

López-Otín, Carlos,

Latorre-Pellicer, Ana,

Cruz, Raquel,

Colás, Carmen,

Lapuente-Brun, Esther,

Pérez-Martos, Acisclo,

Fernández-Vizarra, Erika,

Enríquez, José Antonio

2013

Overview

The textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This model (known as the fluid model) is challenged by the proposal that all RCs except complex II can associate in supercomplexes (SCs). The proposed SCs are the respirasome (complexes I, III, and IV), complexes I and III, and complexes III and IV. The role of SCs is unclear, and their existence is debated. By genetic modulation of interactions between complexes I and III and III and IV, we show that these associations define dedicated CoQ and cyt c pools and that SC assembly is dynamic and organizes electron flux to optimize the use of available substrates.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

/ Animals

/ Cytochromes c - metabolism

/ Electron Transport