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Phase 3 Trial of Ibrutinib plus Rituximab in Waldenström’s Macroglobulinemia
by
Trotman, Judith
, Treon, Steven P
, Herbaux, Charles
, Tam, Constantine
, Li, Jianling
, Orsucci, Lorella
, Salman, Zeena
, Buske, Christian
, Macdonald, David
, Tedeschi, Alessandra
, García-Sanz, Ramón
, Palomba, M. Lia
, Mahe, Beatrice
, Graef, Thorsten
, Leblond, Veronique
, Shustik, Chaim
, Dimopoulos, Meletios A
, Matous, Jeffrey V
, Kastritis, Efstathios
in
Adult
/ Aged
/ Aged, 80 and over
/ Antineoplastic Combined Chemotherapy Protocols - adverse effects
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Arthralgia
/ Atrial Fibrillation - chemically induced
/ B-cell lymphoma
/ Bone marrow
/ Cancer
/ CXCR4 protein
/ Diarrhea
/ Disease-Free Survival
/ Female
/ Fibrillation
/ Hemoglobin
/ Hemoglobins - analysis
/ Hemorrhage
/ Hospitals
/ Humans
/ Hypertension
/ Immunoglobulin M
/ Immunoglobulin M - blood
/ Immunotherapy
/ Infusions, Intravenous - adverse effects
/ Inhibitor drugs
/ Lymphocytes B
/ Macroglobulinemia
/ Male
/ Medical research
/ Middle Aged
/ Monoclonal antibodies
/ MyD88 protein
/ Nausea
/ Patients
/ Pyrazoles - administration & dosage
/ Pyrazoles - adverse effects
/ Pyrimidines - administration & dosage
/ Pyrimidines - adverse effects
/ R&D
/ Research & development
/ Response rates
/ Rituximab
/ Rituximab - administration & dosage
/ Rituximab - adverse effects
/ Survival Analysis
/ Targeted cancer therapy
/ Waldenstrom Macroglobulinemia - blood
/ Waldenstrom Macroglobulinemia - drug therapy
2018
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Phase 3 Trial of Ibrutinib plus Rituximab in Waldenström’s Macroglobulinemia
by
Trotman, Judith
, Treon, Steven P
, Herbaux, Charles
, Tam, Constantine
, Li, Jianling
, Orsucci, Lorella
, Salman, Zeena
, Buske, Christian
, Macdonald, David
, Tedeschi, Alessandra
, García-Sanz, Ramón
, Palomba, M. Lia
, Mahe, Beatrice
, Graef, Thorsten
, Leblond, Veronique
, Shustik, Chaim
, Dimopoulos, Meletios A
, Matous, Jeffrey V
, Kastritis, Efstathios
in
Adult
/ Aged
/ Aged, 80 and over
/ Antineoplastic Combined Chemotherapy Protocols - adverse effects
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Arthralgia
/ Atrial Fibrillation - chemically induced
/ B-cell lymphoma
/ Bone marrow
/ Cancer
/ CXCR4 protein
/ Diarrhea
/ Disease-Free Survival
/ Female
/ Fibrillation
/ Hemoglobin
/ Hemoglobins - analysis
/ Hemorrhage
/ Hospitals
/ Humans
/ Hypertension
/ Immunoglobulin M
/ Immunoglobulin M - blood
/ Immunotherapy
/ Infusions, Intravenous - adverse effects
/ Inhibitor drugs
/ Lymphocytes B
/ Macroglobulinemia
/ Male
/ Medical research
/ Middle Aged
/ Monoclonal antibodies
/ MyD88 protein
/ Nausea
/ Patients
/ Pyrazoles - administration & dosage
/ Pyrazoles - adverse effects
/ Pyrimidines - administration & dosage
/ Pyrimidines - adverse effects
/ R&D
/ Research & development
/ Response rates
/ Rituximab
/ Rituximab - administration & dosage
/ Rituximab - adverse effects
/ Survival Analysis
/ Targeted cancer therapy
/ Waldenstrom Macroglobulinemia - blood
/ Waldenstrom Macroglobulinemia - drug therapy
2018
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Phase 3 Trial of Ibrutinib plus Rituximab in Waldenström’s Macroglobulinemia
by
Trotman, Judith
, Treon, Steven P
, Herbaux, Charles
, Tam, Constantine
, Li, Jianling
, Orsucci, Lorella
, Salman, Zeena
, Buske, Christian
, Macdonald, David
, Tedeschi, Alessandra
, García-Sanz, Ramón
, Palomba, M. Lia
, Mahe, Beatrice
, Graef, Thorsten
, Leblond, Veronique
, Shustik, Chaim
, Dimopoulos, Meletios A
, Matous, Jeffrey V
, Kastritis, Efstathios
in
Adult
/ Aged
/ Aged, 80 and over
/ Antineoplastic Combined Chemotherapy Protocols - adverse effects
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Arthralgia
/ Atrial Fibrillation - chemically induced
/ B-cell lymphoma
/ Bone marrow
/ Cancer
/ CXCR4 protein
/ Diarrhea
/ Disease-Free Survival
/ Female
/ Fibrillation
/ Hemoglobin
/ Hemoglobins - analysis
/ Hemorrhage
/ Hospitals
/ Humans
/ Hypertension
/ Immunoglobulin M
/ Immunoglobulin M - blood
/ Immunotherapy
/ Infusions, Intravenous - adverse effects
/ Inhibitor drugs
/ Lymphocytes B
/ Macroglobulinemia
/ Male
/ Medical research
/ Middle Aged
/ Monoclonal antibodies
/ MyD88 protein
/ Nausea
/ Patients
/ Pyrazoles - administration & dosage
/ Pyrazoles - adverse effects
/ Pyrimidines - administration & dosage
/ Pyrimidines - adverse effects
/ R&D
/ Research & development
/ Response rates
/ Rituximab
/ Rituximab - administration & dosage
/ Rituximab - adverse effects
/ Survival Analysis
/ Targeted cancer therapy
/ Waldenstrom Macroglobulinemia - blood
/ Waldenstrom Macroglobulinemia - drug therapy
2018
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Phase 3 Trial of Ibrutinib plus Rituximab in Waldenström’s Macroglobulinemia
Journal Article
Phase 3 Trial of Ibrutinib plus Rituximab in Waldenström’s Macroglobulinemia
2018
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Overview
A randomized trial comparing ibrutinib plus rituximab with rituximab alone in patients with Waldenström’s macroglobulinemia showed significantly higher rates of progression-free survival and overall response with the addition of ibrutinib.
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Antineoplastic Combined Chemotherapy Protocols - adverse effects
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Atrial Fibrillation - chemically induced
/ Cancer
/ Diarrhea
/ Female
/ Humans
/ Infusions, Intravenous - adverse effects
/ Male
/ Nausea
/ Patients
/ Pyrazoles - administration & dosage
/ Pyrimidines - administration & dosage
/ Pyrimidines - adverse effects
/ R&D
/ Rituximab - administration & dosage
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