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Preoperative Treatment of Locally Advanced Rectal Cancer

by Musher, Benjamin L. , Saltz, Leonard B. , Goodman, Karyn A. , Farma, Jeffrey M. , Meyerhardt, Jeffrey A. , Dueck, Amylou C. , Mamon, Harvey J. , Al Baghdadi, Tareq , Gollub, Marc J. , Kennecke, Hagen F. , O’Reilly, Eileen M. , Shergill, Ardaman , Schrag, Deborah , Goldberg, Joel , Weiser, Martin R. , George, Thomas J. , McWilliams, Robert R. , Basch, Ethan , Gordon, Vallerie , Colgrove, Brian , Montemurro, Michael , Chang, George J. , Shi, Qian , Nelson, Garth D. , Venook, Alan P.

in 5-Fluorouracil / Adult / Anal Canal - surgery / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Cancer / Cancer therapies / Chemoradiotherapy / Chemoradiotherapy - adverse effects / Chemoradiotherapy - methods / Chemotherapy / Chemotherapy, Adjuvant / Colorectal cancer / Death / Disease-Free Survival / Fluorouracil - administration & dosage / Fluorouracil - adverse effects / Gastroenterology / Gastrointestinal Tract Cancer / Hematology / Humans / Leucovorin - administration & dosage / Leucovorin - adverse effects / Neoadjuvant Therapy / Neoplasm Recurrence, Local - drug therapy / Neoplasm Staging / Oncology / Organ Sparing Treatments / Organoplatinum Compounds / Oxaliplatin / Oxaliplatin - administration & dosage / Oxaliplatin - adverse effects / Pathology / Patients / Pelvis / Preoperative Care / Preoperative Period / Radiation therapy / Rectal Neoplasms - mortality / Rectal Neoplasms - pathology / Rectal Neoplasms - surgery / Rectum / Review boards / Sphincter / Statistical analysis / Surgeons / Surgery / Survival / Treatments in Oncology / Tumors

2023

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Preoperative Treatment of Locally Advanced Rectal Cancer

2023

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2023

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Journal Article

Preoperative Treatment of Locally Advanced Rectal Cancer

Musher, Benjamin L.,

Saltz, Leonard B.,

Goodman, Karyn A.,

Farma, Jeffrey M.,

Meyerhardt, Jeffrey A.,

Dueck, Amylou C.,

Mamon, Harvey J.,

Al Baghdadi, Tareq,

Gollub, Marc J.,

Kennecke, Hagen F.,

O’Reilly, Eileen M.,

Shergill, Ardaman,

Schrag, Deborah,

Goldberg, Joel,

Weiser, Martin R.,

George, Thomas J.,

McWilliams, Robert R.,

Basch, Ethan,

Gordon, Vallerie,

Colgrove, Brian,

Montemurro, Michael,

Chang, George J.,

Shi, Qian,

Nelson, Garth D.,

Venook, Alan P.

2023

Overview

In a trial comparing preoperative chemoradiotherapy and FOLFOX in patients with rectal cancer undergoing sphincter-sparing surgery, 5-year disease-free survival was 80.8% with FOLFOX and 78.6% with chemoradiotherapy.

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Publisher

Massachusetts Medical Society

Subject

5-Fluorouracil

/ Adult

/ Anal Canal - surgery

/ Antineoplastic Combined Chemotherapy Protocols - adverse effects

/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use

/ Cancer

/ Cancer therapies