Asset Details
Do you wish to reserve the book?
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans
Do you wish to request the book?
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans
2025
Overview
Circulating Growth Differentiation Factors 11 and 8 (GDF11/8) exist in both latent and active forms, and it is unclear if specific forms can predict disease outcomes. Our data suggest that a dual-specific aptamer selectively binds GDF11/8 after prodomain activation. In 11,609 patients at risk for future cardiovascular events, low dual-specific aptamer-detected GDF11/8 levels strongly predicted adverse outcomes, including cardiovascular events (HR = 0.43,
p
= 9.1 × 10⁻⁶³) and all-cause mortality (HR = 0.33,
p
= 4.8 × 10⁻⁴⁰). Use of selective aptamers suggested that results observed with the dual-specific aptamer for cardiovascular and mortality risk replicated with a GDF8 aptamer although with a smaller effect size. In a second cohort of 4110 individuals (ARIC), low dual-specific aptamer-detected GDF11/8 levels also predicted increased 8 year dementia risk (HR = 0.66,
p
= 0.00148). Our findings reveal that activation of GDF11/8 may be a factor in future aging-related cardiovascular and cognitive decline.
The predictive value of blood levels of GDF11/8 proteins in humans for future disease outcomes has been unclear. Here, the authors show that low levels of specific activated GDF11/8 subforms are strongly associated with future cardiovascular events, mortality, and dementia risk.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 82/58
/ 82/79
/ Aged
/ Aptamers
/ Aptamers, Nucleotide - metabolism
/ Bone Morphogenetic Proteins - blood
/ Bone Morphogenetic Proteins - metabolism
/ Cardiovascular Diseases - blood
/ Cardiovascular Diseases - mortality
/ Female
/ Growth Differentiation Factors - blood
/ Growth Differentiation Factors - metabolism
/ Humanities and Social Sciences
/ Humans
/ Ligands
/ Male
/ Proteins
/ Risk
/ Science
