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LAT1-NRF2 axis controls sFlt-1/PlGF imbalance and oxidative stress in preeclampsia
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LAT1-NRF2 axis controls sFlt-1/PlGF imbalance and oxidative stress in preeclampsia
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Journal Article
LAT1-NRF2 axis controls sFlt-1/PlGF imbalance and oxidative stress in preeclampsia
2025
Overview
Preeclampsia (PE) is a complex disease with unclear etiology. It is the most dangerous human pregnancy disease, causing morbidity and mortality in thousands of women and newborns worldwide. The soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is currently the best and only predictive biomarker. The higher the ratio, the more likely the pregnant women will develop PE. The molecular mechanism underlying the increased sFlt-1/PlGF ratio is not known. Here, we show that amino acid transporter LAT1 (
SLC7A5
) and transcription factor NRF2 regulate this ratio via a previously unknown mechanism to produce sFlt-1 and PlGF in an anti-angiogenic ratio as observed in PE. In addition, we show that PE-associated oxidative stress, whose origin was unknown, is a secondary phenomenon caused by reduced NRF2 and LAT1 activity. The interdependence of the involved proteins, including also ATF4, Flt-1 and Akt, indicates that any disruption of the interaction would ultimately lead to a PE-like phenotype.
Reduced placental angiogenesis is suspected to cause preeclampsia. Using placental in vitro models and an in vivo model, the authors uncover the key role of an amino acid transporter and related molecular interactions that together induce an anti-angiogenic state, as observed in preeclampsia.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/1
/ 13/106
/ 38
/ 38/109
/ 38/77
/ 38/90
/ 64
/ 64/60
/ 82/80
/ Female
/ Humanities and Social Sciences
/ Humans
/ Kinases
/ Large Neutral Amino Acid-Transporter 1 - genetics
/ Large Neutral Amino Acid-Transporter 1 - metabolism
/ Neonates
/ NF-E2-Related Factor 2 - genetics
/ NF-E2-Related Factor 2 - metabolism
/ Placenta
/ Placenta Growth Factor - blood
/ Placenta Growth Factor - genetics
/ Placenta Growth Factor - metabolism
/ Proteins
/ Science
/ Tyrosine
/ Vascular endothelial growth factor
/ Vascular Endothelial Growth Factor Receptor-1 - blood
/ Vascular Endothelial Growth Factor Receptor-1 - genetics
/ Vascular Endothelial Growth Factor Receptor-1 - metabolism
