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The extracellular matrix in myocardial injury, repair, and remodeling
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The extracellular matrix in myocardial injury, repair, and remodeling
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Journal Article
The extracellular matrix in myocardial injury, repair, and remodeling
2017
Overview
The cardiac extracellular matrix (ECM) not only provides mechanical support, but also transduces essential molecular signals in health and disease. Following myocardial infarction, dynamic ECM changes drive inflammation and repair. Early generation of bioactive matrix fragments activates proinflammatory signaling. The formation of a highly plastic provisional matrix facilitates leukocyte infiltration and activates infarct myofibroblasts. Deposition of matricellular proteins modulates growth factor signaling and contributes to the spatial and temporal regulation of the reparative response. Mechanical stress due to pressure and volume overload and metabolic dysfunction also induce profound changes in ECM composition that contribute to the pathogenesis of heart failure. This manuscript reviews the role of the ECM in cardiac repair and remodeling and discusses matrix-based therapies that may attenuate remodeling while promoting repair and regeneration.
Publisher
American Society for Clinical Investigation
Subject
/ Collagen
/ Extracellular Matrix - immunology
/ Extracellular Matrix - metabolism
/ Extracellular Matrix - pathology
/ Extracellular Matrix Proteins - immunology
/ Extracellular Matrix Proteins - metabolism
/ Heart Failure, Diastolic - immunology
/ Heart Failure, Diastolic - metabolism
/ Heart Failure, Diastolic - pathology
/ Humans
/ Intercellular Signaling Peptides and Proteins - immunology
/ Intercellular Signaling Peptides and Proteins - metabolism
/ Ischemia
/ Myocardial Infarction - immunology
/ Myocardial Infarction - metabolism
/ Myocardial Infarction - pathology
/ Myocytes, Cardiac - immunology
/ Myocytes, Cardiac - metabolism
/ Myocytes, Cardiac - pathology
/ Plastics
/ Proteins
/ Review
/ Rodents
