Asset Details
Do you wish to reserve the book?
Influence of Gestational Age and Body Weight on the Pharmacokinetics of Labetalol in Pregnancy
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Influence of Gestational Age and Body Weight on the Pharmacokinetics of Labetalol in Pregnancy
Do you wish to request the book?
Influence of Gestational Age and Body Weight on the Pharmacokinetics of Labetalol in Pregnancy
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Influence of Gestational Age and Body Weight on the Pharmacokinetics of Labetalol in Pregnancy
2014
Overview
Background and Objectives
Labetalol is frequently prescribed for the treatment of hypertension during pregnancy; however, the influence of pregnancy on labetalol pharmacokinetics is uncertain, with inconsistent findings reported by previous studies. This study examined the population pharmacokinetics of oral labetalol during and after pregnancy in women receiving labetalol for hypertension.
Methods
Data were collected from 57 women receiving the drug for hypertension from the 12th week of pregnancy through 12 weeks postpartum using a prospective, longitudinal design. A sparse sampling strategy guided collection of plasma samples. Samples were assayed for labetalol by high-performance liquid chromatography. Estimation of population pharmacokinetic parameters and covariate effects was performed by nonlinear mixed effects modeling using NONMEM. The final population model was validated by bootstrap analysis and visual predictive check. Simulations were performed with the final model to evaluate the appropriate body weight to guide labetalol dosing.
Results
Lean body weight (LBW) and gestational age, i.e. weeks of pregnancy, were identified as significantly influencing oral clearance (CL/
F
) of labetalol, with CL/
F
ranging from 1.4-fold greater than postpartum values at 12 weeks’ gestational age to 1.6-fold greater at 40 weeks. Doses adjusted for LBW provide more consistent drug exposure than doses adjusted for total body weight. The apparent volumes of distribution for the central compartment and at steady-state were 1.9-fold higher during pregnancy.
Conclusions
Gestational age and LBW impact the pharmacokinetics of labetalol during pregnancy and have clinical implications for adjusting labetalol doses in these women.
Publisher
Springer International Publishing,Adis International,Springer Nature B.V
Subject
/ Adult
/ Antihypertensive Agents - pharmacokinetics
/ Antihypertensive Agents - therapeutic use
/ Biological and medical sciences
/ Dose-Response Relationship, Drug
/ Female
/ Humans
/ Hypertension, Pregnancy-Induced - drug therapy
/ Labetalol - pharmacokinetics
/ Medicine
/ Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
