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Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia

by Akarca, Ayse , Quezada, Sergio A , Sarwar, Naveed , Seckl, Michael J , Marafioti, Teresa , Carlson, Joseph W , Short, Dee , Joneborg, Ulrika , Fisher, Rosemary A , Kaur, Baljeet , Ghorani, Ehsan

in Adult / Antibodies, Monoclonal, Humanized - therapeutic use / Anticancer properties / Antigens / Apoptosis / B7-H1 Antigen - genetics / B7-H1 Antigen - metabolism / Biomarkers / Biomarkers, Tumor - metabolism / Biomedical research / Brain / Brain research / Cancer therapies / Cell death / Chemotherapy / Cytotoxicity / Disease / Drug dosages / Drug resistance / Drug Resistance, Neoplasm / Female / Funding / Gestational Trophoblastic Disease - diagnosis / Gestational Trophoblastic Disease - drug therapy / Gestational Trophoblastic Disease - genetics / Humans / Immunotherapy / Ligands / Liver / Liver diseases / Lymphocytes / Lymphocytes T / Medical research / Metastases / Metastasis / Middle Aged / Molecular Targeted Therapy - methods / Monoclonal antibodies / Patient Safety / Patients / PD-1 protein / PD-L1 protein / Pembrolizumab / Placenta / Pregnancy / R&D / Research & development / Research centers / Risk analysis / Risk factors / Sampling Studies / Targeted cancer therapy / Treatment Outcome / Tumors / United Kingdom / Uterine Neoplasms - diagnosis / Uterine Neoplasms - drug therapy / Uterine Neoplasms - genetics

2017

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Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia

by Akarca, Ayse , Quezada, Sergio A , Sarwar, Naveed , Seckl, Michael J , Marafioti, Teresa , Carlson, Joseph W , Short, Dee , Joneborg, Ulrika , Fisher, Rosemary A , Kaur, Baljeet , Ghorani, Ehsan

2017

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Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia

by Akarca, Ayse , Quezada, Sergio A , Sarwar, Naveed , Seckl, Michael J , Marafioti, Teresa , Carlson, Joseph W , Short, Dee , Joneborg, Ulrika , Fisher, Rosemary A , Kaur, Baljeet , Ghorani, Ehsan

2017

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Journal Article

Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia

Akarca, Ayse,

Quezada, Sergio A,

Sarwar, Naveed,

Seckl, Michael J,

Marafioti, Teresa,

Carlson, Joseph W,

Short, Dee,

Joneborg, Ulrika,

Fisher, Rosemary A,

Kaur, Baljeet,

Ghorani, Ehsan

2017

Overview

Gestational trophoblastic disease represents a spectrum of pregnancy related disorders, ranging from pre-malignant hydatidiform mole to malignant tumours, collectively referred to as gestational trophoblastic neoplasia. Gestational trophoblastic neoplasia includes malignant invasive mole, choriocarcinoma, and rare placental site trophoblastic and epithelioid trophoblastic tumours.1

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Publisher

Elsevier Ltd,Elsevier Limited

Subject

Adult

/ Antibodies, Monoclonal, Humanized - therapeutic use

/ Anticancer properties

/ Antigens

/ Apoptosis

/ B7-H1 Antigen - genetics

/ B7-H1 Antigen - metabolism