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Activating Killer Immunoglobulin Receptors and HLA-C: a successful combination providing HIV-1 control

by Poli, Guido , Malnati, Mauro S. , Tarkowski, Maciej , Ugolotti, Elisabetta , De Maria, Andrea , Sironi, Francesca , Tambussi, Giuseppe , Battista, Davide De , Vanni, Irene , Marco, Eddi Di , Biswas, Priscilla , Vicenzi, Elisa , Riva, Agostino , Tripodi, Gino , Pistorio, Angela , Bordo, Domenico , Biassoni, Roberto , Nozza, Silvia , Larghero, Patrizia , Monti, Maria Cristina , Marras, Francesco

in 13 / 13/106 / 13/31 / 45 / 45/77 / 631/250/248 / 631/326/596/2557 / Alleles / CD4-Positive T-Lymphocytes - immunology / CD4-Positive T-Lymphocytes - metabolism / CD4-Positive T-Lymphocytes - virology / CD8 antigen / Chromosomes, Human, Pair 19 / Chromosomes, Human, Pair 6 / Disease Progression / Genetic Predisposition to Disease / Genotype / Histocompatibility antigen HLA / Histocompatibility Antigens Class I - genetics / Histocompatibility Antigens Class I - immunology / HIV Infections - genetics / HIV Infections - immunology / HIV Infections - metabolism / HIV Infections - virology / HIV-1 - immunology / HLA-C Antigens - genetics / HLA-C Antigens - immunology / Host-Pathogen Interactions - genetics / Host-Pathogen Interactions - immunology / Humanities and Social Sciences / Humans / Immunoglobulin receptors / Immunoglobulins / Lymphocytes T / multidisciplinary / Odds Ratio / Polymorphism, Genetic / Receptors, KIR - agonists / Receptors, KIR - genetics / Receptors, KIR - metabolism / Science / Viremia

2017

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Activating Killer Immunoglobulin Receptors and HLA-C: a successful combination providing HIV-1 control

2017

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2017

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Journal Article

Activating Killer Immunoglobulin Receptors and HLA-C: a successful combination providing HIV-1 control

Poli, Guido,

Malnati, Mauro S.,

Tarkowski, Maciej,

Ugolotti, Elisabetta,

De Maria, Andrea,

Sironi, Francesca,

Tambussi, Giuseppe,

Battista, Davide De,

Vanni, Irene,

Marco, Eddi Di,

Biswas, Priscilla,

Vicenzi, Elisa,

Riva, Agostino,

Tripodi, Gino,

Pistorio, Angela,

Bordo, Domenico,

Biassoni, Roberto,

Nozza, Silvia,

Larghero, Patrizia,

Monti, Maria Cristina,

Marras, Francesco

2017

Overview

Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ 13/106

/ 13/31

/ 45

/ 45/77

/ 631/250/248

/ 631/326/596/2557

/ Alleles