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Journal Article
S100A6 protein: functional roles
2017
Overview
S100A6 protein belongs to the A group of the S100 protein family of Ca
2+
-binding proteins. It is expressed in a limited number of cell types in adult normal tissues and in several tumor cell types. As an intracellular protein, S100A6 has been implicated in the regulation of several cellular functions, such as proliferation, apoptosis, the cytoskeleton dynamics, and the cellular response to different stress factors. S100A6 can be secreted/released by certain cell types which points to extracellular effects of the protein. RAGE (receptor for advanced glycation endproducts) and integrin β1 transduce some extracellular S100A6’s effects. Dosage of serum S100A6 might aid in diagnosis in oncology.
Publisher
Springer International Publishing,Springer Nature B.V
Subject
/ advanced glycation end products
/ Advanced glycosylation end products
/ Animals
/ Binding
/ Biomedical and Life Sciences
/ Calcium
/ Cell Cycle Proteins - genetics
/ Cell Cycle Proteins - metabolism
/ Dosage
/ Humans
/ Neurodegenerative Diseases - genetics
/ Neurodegenerative Diseases - metabolism
/ Proteins
/ Receptor for Advanced Glycation End Products - metabolism
/ Review
/ S100 Calcium Binding Protein A6
/ Tissues
