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Comparative analysis of the gut microbiota in distinct statin response patients in East China
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Comparative analysis of the gut microbiota in distinct statin response patients in East China
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Journal Article
Comparative analysis of the gut microbiota in distinct statin response patients in East China
2018
Overview
Statin response shows great interindividual variations. Recently, emerging studies have shown that gut microbiota is linked to therapeutic responses to drugs, including statins. However, the association between the gut bacteria composition and statin response is still unclear. In this study, gut microbiota of 202 hyperlipidemic patients with statin sensitive (SS) response and statin resistant (SR) response in East China were investigated by high throughput sequencing to compare the gut bacteria composition and biodiversity in distinct statin response patients. Higher biodiversity was detected in Group SS than Group SR. Specifically, group SS showed significantly increased proportion of genera
Lactobacillus
(P = 0.001),
Eubacterium
(P = 0.004),
Faecalibacterium
(P = 0.005), and
Bifidobacterium
(P = 0.002) and decreased proportion of genus
Clostridium
(P = 0.001) compared to Group SR. The results indicated that higher gut biodiversity was associated with statin sensitive response. The increased genera
Lactobacillus
,
Eubacterium
,
Faecalibacterium
,
Bifidobacterium
, and decreased genus
Clostridium
in patient gut microbiota may predict patient's statin response, and hence may guide statin dosage adjustments.
Publisher
The Microbiological Society of Korea,Springer Nature B.V,한국미생물학회
Subject
/ Bifidobacterium - drug effects
/ Biomedical and Life Sciences
/ China
/ drugs
/ Faecalibacterium - drug effects
/ Gastrointestinal Microbiome - drug effects
/ Gastrointestinal Microbiome - genetics
/ Gastrointestinal Tract - microbiology
/ High-Throughput Nucleotide Sequencing
/ Humans
/ Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
/ Hypercholesterolemia - drug therapy
/ Lactobacillus - drug effects
/ Male
/ Patients
/ Statins
/ 생물학
