Journal Article

Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, México

Dévora-Figueroa, Ana G., Burgess, Jefferey L., Vega-Millán, Christian B., Meza-Montenegro, Maria M., Meza-Escalante, Edna R., Balderas-Cortés, José J., Meza-Figueroa, Diana, García-Rico, Leticia, Furlong, Melissa, O´Rourke, Mary Kay, Beamer, Paloma I., Lantz, R. Clark

2021

Overview

Environmental arsenic exposure in adults and children has been associated with a reduction in the expression of club cell secretory protein (CC16) and an increase in the expression of matrix metalloproteinase-9 (MMP-9), both biomarkers of lung inflammation and negative respiratory outcomes. The objectives of this study were to determine if the levels of serum CC16 and MMP-9 and subsequent respiratory infections in children are associated with the ingestion of arsenic by drinking water. This cross-sectional study included 216 children from three Yaqui villages, Potam, Vicam, and Cocorit, with levels of arsenic in their ground water of 70.01 ± 21.85, 23.3 ± 9.99, and 11.8 ± 4.42 μg/L respectively. Total arsenic in water and urine samples was determined by inductively coupled plasma/optical emission spectrometry. Serum was analyzed for CC16 and MMP-9 using ELISA. The children had an average urinary arsenic of 79.39 μg/L and 46.8 % had levels above of the national concern value of 50 μg/L. Increased arsenic concentrations in drinking water and average daily arsenic intake by water were associated with decreased serum CC16 levels (β = − 0.12, 95% CI − 0.20, − 0.04 and β = − 0.10, 95% CI − 0.18, − 0.03), and increased serum MMP-9 levels (β = 0.35, 95% CI 0.22, 0.48 and β = 0.29, 95% CI 0.18, 0.40) at significant levels ( P < 0.05). However, no association was found between levels of these serum biomarkers and urinary arsenic concentrations. In these children, reduced serum CC16 levels were significantly associated with increased risk of respiratory infections (OR = 0.34, 95% CI 0.13, 0.90). In conclusion, altered levels of serum CC16 and MMP-9 in the children may be due to the toxic effects of arsenic exposure through drinking water.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Aquatic Pollution / Arsenic / Atmospheric Protection/Air Quality Control/Air Pollution / Biomarkers / blood serum / Children / cross-sectional studies / Drinking water / Earth and Environmental Science / Ecotoxicology / Emission analysis / Environment / Environmental Chemistry / Environmental Health / Environmental science / Exposure / Gelatinase B / Groundwater / Inductively coupled plasma / Inflammation / Ingestion / lungs / Matrix metalloproteinase / Matrix metalloproteinases / Metalloproteinase / Mexico / Optical emission spectroscopy / pollution / Research Article / risk / Spectrometry / spectroscopy / toxicity / urine / Villages / Waste Water Technology / Water Management / Water Pollution Control