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Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus

by Kim, Dong-Hwi , Park, Seung-Yong , Kim, Jae-Hyeong , Han, Sang-Hoon , Go, Hyeon-Jeong , Lee, Joong-Bok , Song, Chang-Seon , Lee, Sang-Won , Kim, Da-Yoon , Choi, In-Soo

in Adenoviruses / Antiviral activity / Antiviral drugs / Canine distemper / Cell lines / Coronaviruses / Cytotoxicity / Disease transmission / Epithelial cells / Infections / Infectious diseases / Interferon / Parvoviruses / Pathogens / Veterinary medicine / Viral diseases / Viruses

2022

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Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus

by Kim, Dong-Hwi , Park, Seung-Yong , Kim, Jae-Hyeong , Han, Sang-Hoon , Go, Hyeon-Jeong , Lee, Joong-Bok , Song, Chang-Seon , Lee, Sang-Won , Kim, Da-Yoon , Choi, In-Soo

2022

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Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus

by Kim, Dong-Hwi , Park, Seung-Yong , Kim, Jae-Hyeong , Han, Sang-Hoon , Go, Hyeon-Jeong , Lee, Joong-Bok , Song, Chang-Seon , Lee, Sang-Won , Kim, Da-Yoon , Choi, In-Soo

2022

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Journal Article

Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus

Kim, Dong-Hwi,

Park, Seung-Yong,

Kim, Jae-Hyeong,

Han, Sang-Hoon,

Go, Hyeon-Jeong,

Lee, Joong-Bok,

Song, Chang-Seon,

Lee, Sang-Won,

Kim, Da-Yoon,

Choi, In-Soo

2022

Overview

Abstract Canine coronavirus (CCoV), canine parvovirus (CPV), and canine distemper virus (CDV) are highly contagious canine pathogens; dogs with these diseases are difficult to treat. In a previous study, we developed a recombinant adenovirus expressing canine interferon lambda 3 (Ad-caIFNλ3) in canine epithelial cells. In this study, we aimed to investigate the antiviral activity of Ad-caIFNλ3 against CCoV, CPV, and CDV in two canine cell lines, A72 and MDCK. Ad-caIFNλ3 transduction suppressed replication of these viruses without cytotoxicity. Our results suggest that Ad-caIFNλ3 may be a therapeutic candidate for canine viral diseases.

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Springer Nature B.V

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