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Treatment of Multisystem Inflammatory Syndrome in Children

by Ulloa-Gutierrez, Rolando , Carter, Michael J , Wilson, Clare , Broderick, Claire , Kaforou, Myrsini , Nijman, Ruud , Patel, Harsita , Seaby, Eleanor G , Tremoulet, Adriana H , Hoggart, Clive , Whittaker, Elizabeth , Levin, Michael , Shah, Priyen , Herberg, Jethro A , Cunnington, Aubrey J , McArdle, Andrew J , Munblit, Daniel , De, Tisham , Vito, Ortensia

in Adolescent / Allergy / Aneurysms / Antibodies, Viral / Child / Child, Preschool / Childhood Diseases / Children / Cohort Studies / Confidence Intervals / Coronavirus / Coronaviruses / COVID-19 / COVID-19 - immunology / COVID-19 - mortality / COVID-19 - therapy / COVID-19 Drug Treatment / Disease / Drug Therapy, Combination / Female / Globulins / Glucocorticoids / Glucocorticoids - therapeutic use / Hospitalization / Humans / Immunoglobulins / Immunoglobulins, Intravenous - therapeutic use / Immunology / Immunology General / Immunomodulation / Infections / Infectious Disease / Inflammation / Intravenous administration / Laboratories / Male / Mechanical ventilation / Multisystem inflammatory syndrome in children / Original / Patients / Pediatrics / Pediatrics General / Propensity Score / Proteins / Regression Analysis / Respiration, Artificial / SARS-CoV-2 - immunology / Severe acute respiratory syndrome coronavirus 2 / Statistical analysis / Systemic Inflammatory Response Syndrome - drug therapy / Systemic Inflammatory Response Syndrome - immunology / Systemic Inflammatory Response Syndrome - mortality / Systemic Inflammatory Response Syndrome - therapy / Treatment Outcome / Veins & arteries / Ventilation

2021

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2021

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Treatment of Multisystem Inflammatory Syndrome in Children

2021

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Journal Article

Treatment of Multisystem Inflammatory Syndrome in Children

Ulloa-Gutierrez, Rolando,

Carter, Michael J,

Wilson, Clare,

Broderick, Claire,

Kaforou, Myrsini,

Nijman, Ruud,

Patel, Harsita,

Seaby, Eleanor G,

Tremoulet, Adriana H,

Hoggart, Clive,

Whittaker, Elizabeth,

Levin, Michael,

Shah, Priyen,

Herberg, Jethro A,

Cunnington, Aubrey J,

McArdle, Andrew J,

Munblit, Daniel,

De, Tisham,

Vito, Ortensia

2021

Overview

An observational cohort study evaluated immunomodulatory therapy of multisystem inflammatory syndrome in children by comparing IVIG, IVIG plus glucocorticoids, or glucocorticoids alone. The investigators found no evidence of the superiority of any of the three therapies, although significant differences may emerge as more data accrue.

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Publisher

Massachusetts Medical Society

Subject

/ Allergy

/ Child