Journal Article

Persistence of Ebola Virus in Ocular Fluid during Convalescence

Varkey, Jay B, Ribner, Bruce S, Kumar, Gokul, Ströher, Ute, Kainulainen, Markus H, Smith, Justine R, Yeh, Steven, Shantha, Jessica G, Whitmer, Shannon, Kraft, Colleen S, Mehta, Aneesh K, Crozier, Ian, Lyon, G. Marshall, Uyeki, Timothy M

2015

Overview

In this report, Ebola virus was cultured from aqueous humor 14 weeks after disease onset and 9 weeks after resolution of viremia, a finding that indicates the potential for delayed clearance of the virus from immune-privileged sites. The current outbreak of EVD is believed to have begun in December 2013. 1 As of April 26, 2015, a total of 26,312 cases of EVD (including 10,899 deaths) had been reported in six countries in West Africa (i.e., Sierra Leone, Liberia, Guinea, Mali, Nigeria, and Senegal), the United States, the United Kingdom, and Spain. 2 The outbreak has also resulted in the largest number of EVD survivors in history. Among survivors of EVD, late complications that include ocular disease can develop during convalescence. 3 , 4 However, few systematic studies have been conducted on post-EVD sequelae, so the incidence and clinical manifestations of . . .

• Publisher: Massachusetts Medical Society
• Subject: Adult / Aqueous Humor - virology / Convalescence / Ebola virus / Ebolavirus / Ebolavirus - isolation & purification / Eye diseases / Fundus Oculi / Hemorrhagic Fever, Ebola - complications / Humans / Male / Panuveitis - virology / Pathogenesis / Uveitis / Viremia / Vision Disorders - virology