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Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development
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Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development
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Journal Article
Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development
2016
Overview
The maternally inherited alpha-proteobacterium
Wolbachia
has been proposed as a tool to block transmission of devastating mosquito-borne infectious diseases like dengue and malaria. Here we study the reproductive manipulations induced by a recently identified
Wolbachia
strain that stably infects natural mosquito populations of a major malaria vector,
Anopheles coluzzii
, in Burkina Faso. We determine that these infections significantly accelerate egg laying but do not induce cytoplasmic incompatibility or sex-ratio distortion, two parasitic reproductive phenotypes that facilitate the spread of other
Wolbachia
strains within insect hosts. Analysis of 221 blood-fed
A. coluzzii
females collected from houses shows a negative correlation between the presence of
Plasmodium
parasites and
Wolbachia
infection. A mathematical model incorporating these results predicts that infection with these endosymbionts may reduce malaria prevalence in human populations. These data suggest that
Wolbachia
may be an important player in malaria transmission dynamics in Sub-Saharan Africa.
Wolbachia
bacteria infect insects and could potentially be used to control populations of malaria-transmitting mosquitoes. Here, the authors provide evidence that natural
Wolbachia
infections affect the rate of egg laying and are associated with reduced presence of malaria parasites in
Anopheles
mosquitoes.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14
/ 14/32
/ 14/63
/ 64
/ Animals
/ Bacteria
/ Disease Transmission, Infectious - prevention & control
/ DNA, Bacterial - isolation & purification
/ Eggs
/ Female
/ Females
/ Humanities and Social Sciences
/ Larva - growth & development
/ Malaria
/ Male
/ Males
/ Mosquito Vectors - microbiology
/ Mosquito Vectors - parasitology
/ Mosquito Vectors - physiology
/ Plasmodium - growth & development
/ RNA, Ribosomal, 16S - genetics
/ Science
