Journal Article

Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities

Jung, Hyo-Il, Jo, Seongbin, Lee, Stephen P., Lee, Sung-Uk, Park, Gyungmin, Seo, Seon Hee, Shin, Joonchul, Oh, Yong Suk, Model, Jeffrey B., Rogers, John A., Lee, Boram, Hourlier-Fargette, Aurélie, Sekine, Yurina, Kwak, Sung Soo, Aranyosi, Alexander J., Reeder, Jonathan T., Han, Sunghyun, Jeong, Hyoyoung, Park, Inkyu, Koo, Jahyun, Kim, Sungbong, Ghaffari, Roozbeh, Seo, Min-Ho, Braun, Paul V., Lee, Geumbee

2020

Overview

Soft microfluidic systems that capture, store, and perform biomarker analysis of microliter volumes of sweat, in situ, as it emerges from the surface of the skin, represent an emerging class of wearable technology with powerful capabilities that complement those of traditional biophysical sensing devices. Recent work establishes applications in the real-time characterization of sweat dynamics and sweat chemistry in the context of sports performance and healthcare diagnostics. This paper presents a collection of advances in biochemical sensors and microfluidic designs that support multimodal operation in the monitoring of physiological signatures directly correlated to physical and mental stresses. These wireless, battery-free, skin-interfaced devices combine lateral flow immunoassays for cortisol, fluorometric assays for glucose and ascorbic acid (vitamin C), and digital tracking of skin galvanic responses. Systematic benchtop evaluations and field studies on human subjects highlight the key features of this platform for the continuous, noninvasive monitoring of biochemical and biophysical correlates of the stress state.

• Publisher: National Academy of Sciences
• Subject: Ascorbic acid / Bioengineering / Biomarkers / Biosensing Techniques / Biosensing Techniques - instrumentation / Cortisol / Dielectric Spectroscopy / Dielectric Spectroscopy - instrumentation / Dielectric Spectroscopy - methods / Electric Impedance / Engineering / Equipment Design / Equipment Design - instrumentation / Equipment Design - methods / Fluorometry / Humans / Immunoassay / Immunoassays / Impedance measurement / Lab-On-A-Chip Devices / Life Sciences / Microfluidics / Microfluidics - methods / Monitoring / Physical Sciences / Sensors / Skin / Skin - chemistry / Sweat / Sweat - chemistry / Vitamin C / Wearable Electronic Devices / Wearable technology